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Atomistry » Sodium » PDB 6c0l-6cgf » 6c7w | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 6c0l-6cgf » 6c7w » |
Sodium in PDB 6c7w: Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate InhibitorEnzymatic activity of Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor
All present enzymatic activity of Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor, PDB code: 6c7w
was solved by
T.S.Peat,
P.Mujumdar,
S.A.Poulsen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6c7w:
The structure of Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor
(pdb code 6c7w). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor, PDB code: 6c7w: Sodium binding site 1 out of 1 in 6c7wGo back to Sodium Binding Sites List in 6c7w
Sodium binding site 1 out
of 1 in the Carbonic Anhydrase 2 in Complex with [(2R,3S,4R,5R)-5-(6-Amino-9H- Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate Inhibitor
Mono view Stereo pair view
Reference:
P.Mujumdar,
S.Bua,
C.T.Supuran,
T.S.Peat,
S.A.Poulsen.
Synthesis, Structure and Bioactivity of Primary Sulfamate-Containing Natural Products. Bioorg. Med. Chem. Lett. V. 28 3009 2018.
Page generated: Tue Dec 15 12:01:35 2020
ISSN: ESSN 1464-3405 PubMed: 29685656 DOI: 10.1016/J.BMCL.2018.04.038 |
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