Sodium in PDB 8stn: Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound

All present enzymatic activity of Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound:
3.6.5.2;

The structure of Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound, PDB code: 8stn was solved by T.H.Tran, S.Dharmaiah, D.K.Simanshu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	73.73 / 2.03
Space group	P 3
Cell size a, b, c (Å), α, β, γ (°)	85.133, 85.133, 41.929, 90, 90, 120
R / Rfree (%)	16 / 18.3

The structure of Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Magnesium	(Mg)	2 atoms

The binding sites of Sodium atom in the Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound (pdb code 8stn). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound, PDB code: 8stn:

Sodium binding site 1 out of 1 in the Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Kras-G12D/G75A Mutant, Gdp-Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Na203 b:43.0 occ:1.00 O A:ASN85 3.6 33.9 1.0 O A:HOH308 3.7 32.8 1.0 ND2 A:ASN85 3.9 31.6 1.0 O A:HOH314 4.4 33.3 1.0 CB A:ASN86 4.5 35.3 1.0 CG A:ASN85 4.6 38.2 1.0 C A:ASN85 4.6 32.7 1.0 CG A:ASN86 4.7 32.7 1.0 ND2 A:ASN86 4.7 36.8 1.0 CA A:ASN86 5.0 32.7 1.0

M.H.Yang, T.H.Tran, B.Hunt, R.Agnor, C.W.Johnson, B.Shui, T.J.Waybright, J.A.Nowak, A.G.Stephen, D.K.Simanshu, K.M.Haigis. Allosteric Regulation of Switch-II Domain Controls Kras Oncogenicity. Cancer Res. 2023.
ISSN: ESSN 1538-7445
PubMed: 37556505
DOI: 10.1158/0008-5472.CAN-22-3210