Sodium in PDB 7sq6: Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution

The binding sites of Sodium atom in the Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution (pdb code 7sq6). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution, PDB code: 7sq6:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:30.0 occ:1.00 OD1 B:ASP471 3.9 19.6 1.0 OD1 A:ASP471 3.9 19.6 1.0 OD1 D:ASP471 3.9 19.6 1.0 OD1 C:ASP471 3.9 19.6 1.0 N A:ASP472 4.7 21.0 1.0 N B:ASP472 4.7 21.0 1.0 N D:ASP472 4.7 21.0 1.0 N C:ASP472 4.7 21.0 1.0 CG B:ASP471 4.9 19.6 1.0 CA B:ASP471 4.9 19.6 1.0 CG A:ASP471 4.9 19.6 1.0 CA A:ASP471 4.9 19.6 1.0 CG D:ASP471 4.9 19.6 1.0 CA D:ASP471 4.9 19.6 1.0 CA C:ASP471 4.9 19.6 1.0 CG C:ASP471 4.9 19.6 1.0 O B:GLY470 5.0 18.0 1.0 O A:GLY470 5.0 18.0 1.0 O C:GLY470 5.0 18.0 1.0 O D:GLY470 5.0 18.0 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Mouse Agonist Ml-SA1-Bound TRPML1 Channel at 2.32 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Na602 b:30.0 occ:1.00 O C:ASN469 4.1 18.0 1.0 O D:ASN469 4.1 18.0 1.0 O B:ASN469 4.2 18.0 1.0 O A:ASN469 4.2 18.0 1.0 O C:GLY470 4.3 18.0 1.0 O B:GLY470 4.3 18.0 1.0 O D:HOH702 4.3 30.0 1.0 O D:GLY470 4.3 18.0 1.0 O A:GLY470 4.4 18.0 1.0 O A:HOH703 4.4 30.0 1.0 O B:HOH703 4.4 30.0 1.0 O C:HOH704 4.4 30.0 1.0 C C:GLY470 4.8 18.0 1.0 C B:GLY470 4.8 18.0 1.0 C D:GLY470 4.8 18.0 1.0 C A:GLY470 4.9 18.0 1.0 CA C:GLY470 5.0 18.0 1.0

N.Gan, Y.Han, W.Zeng, Y.Wang, J.Xue, Y.Jiang. Structural Mechanism of Allosteric Activation of TRPML1 By Pi(3,5)P 2 and Rapamycin. Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
PubMed: 35131932
DOI: 10.1073/PNAS.2120404119