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Atomistry » Sodium » PDB 7app-7b4w » 7avq | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 7app-7b4w » 7avq » |
Sodium in PDB 7avq: Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12)Enzymatic activity of Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12)
All present enzymatic activity of Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12):
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12), PDB code: 7avq
was solved by
A.Chaikuad,
S.Routier,
S.Knapp,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12)
(pdb code 7avq). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12), PDB code: 7avq: Sodium binding site 1 out of 1 in 7avqGo back to![]() ![]()
Sodium binding site 1 out
of 1 in the Crystal Structure of Haspin in Complex with Disubstituted Imidazo[1,2- B]Pyridazine Inhibitor (Compound 12)
![]() Mono view ![]() Stereo pair view
Reference:
J.Elie,
O.Feizbakhsh,
N.Desban,
B.Josselin,
B.Baratte,
A.Bescond,
J.Duez,
X.Fant,
S.Bach,
D.Marie,
M.Place,
S.Ben Salah,
A.Chartier,
S.Berteina-Raboin,
A.Chaikuad,
S.Knapp,
F.Carles,
P.Bonnet,
F.Buron,
S.Routier,
S.Ruchaud.
Design of New Disubstituted Imidazo[1,2- B ]Pyridazine Derivatives As Selective Haspin Inhibitors. Synthesis, Binding Mode and Anticancer Biological Evaluation. J Enzyme Inhib Med Chem V. 35 1840 2020.
Page generated: Tue Oct 8 16:03:04 2024
ISSN: ESSN 1475-6374 PubMed: 33040634 DOI: 10.1080/14756366.2020.1825408 |
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