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Sodium in PDB 6wk2: SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine

Enzymatic activity of SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine

All present enzymatic activity of SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine:
2.1.1.85;

Protein crystallography data

The structure of SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine, PDB code: 6wk2 was solved by S.Dai, J.R.Horton, X.Cheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.65 / 1.76
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 60.342, 175.977, 66.314, 90.00, 92.58, 90.00
R / Rfree (%) 18.2 / 20.7

Sodium Binding Sites:

The binding sites of Sodium atom in the SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine (pdb code 6wk2). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine, PDB code: 6wk2:

Sodium binding site 1 out of 1 in 6wk2

Go back to Sodium Binding Sites List in 6wk2
Sodium binding site 1 out of 1 in the SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of SETD3 Mutant (N255V) in Complex with An Actin Peptide with HIS73 Replaced with Methionine within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Na603

b:49.6
occ:1.00
 N D:SER198 3.4 22.7 1.0
CA D:GLN197 3.8 20.1 1.0
CG2 D:ILE202 3.9 17.0 1.0
CB D:GLN197 4.1 22.0 1.0
C D:GLN197 4.1 22.5 1.0
CG D:GLN197 4.2 27.6 1.0
O D:HOH861 4.2 35.5 1.0
O D:HOH827 4.3 21.5 1.0
CA D:SER198 4.3 25.0 1.0
O D:HOH825 4.4 41.5 1.0
CD1 D:ILE202 4.4 24.2 1.0
CE2 D:PHE206 4.6 26.2 1.0
CZ D:PHE206 4.7 29.2 1.0
O D:HOH1021 4.9 34.8 1.0

Reference:

S.Dai, M.V.Holt, J.R.Horton, C.B.Woodcock, A.Patel, X.Zhang, N.L.Young, A.W.Wilkinson, X.Cheng. Characterization of SETD3 Methyltransferase Mediated Protein Methionine Methylation. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 32503840
DOI: 10.1074/JBC.RA120.014072
Page generated: Tue Oct 8 14:39:23 2024

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