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Sodium in PDB 6u6c: Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form

Enzymatic activity of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form

All present enzymatic activity of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form, PDB code: 6u6c was solved by C.Chang, K.Michalska, N.I.Maltseva, R.Jedrzejczak, P.Mccarren, P.P.Nag, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.88 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 135.106, 159.226, 164.973, 90.00, 90.00, 90.00
R / Rfree (%) 15.3 / 19.5

Other elements in 6u6c:

The structure of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Potassium (K) 8 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form (pdb code 6u6c). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form, PDB code: 6u6c:

Sodium binding site 1 out of 1 in 6u6c

Go back to Sodium Binding Sites List in 6u6c
Sodium binding site 1 out of 1 in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Na825

b:61.1
occ:1.00
 O F:HOH945 2.8 32.4 1.0
O F:HOH1044 2.9 33.8 1.0
O F:GLY67 2.9 30.3 1.0
O F:PRO69 3.0 32.4 1.0
O H:GLY67 3.3 31.7 1.0
O H:PRO69 3.5 27.5 1.0
OE1 B:GLN52 3.8 27.7 0.3
O H:HOH655 3.9 42.9 1.0
OE1 B:GLN52 3.9 28.0 0.3
O F:HOH937 4.0 34.9 1.0
O H:HOH754 4.1 36.9 1.0
C F:GLY67 4.1 23.2 1.0
C F:PRO69 4.2 17.7 1.0
O1 F:FMT823 4.3 56.1 1.0
C H:GLY67 4.4 24.8 1.0
NE2 B:GLN52 4.4 9.9 0.3
N F:PRO69 4.4 23.4 1.0
C F:ARG68 4.4 23.6 1.0
O F:ARG68 4.5 29.6 1.0
CD B:GLN52 4.5 25.2 0.3
O2 F:FMT823 4.6 59.4 1.0
C H:PRO69 4.7 22.9 1.0
CD F:PRO69 4.7 26.7 1.0
C F:FMT823 4.7 61.8 1.0
CD B:GLN52 4.8 25.4 0.3
C H:ARG68 4.8 16.6 1.0
O H:ARG68 4.8 20.9 1.0
CA F:GLY67 4.8 26.2 1.0
N H:PRO69 4.9 20.3 1.0
NE2 B:GLN52 4.9 10.1 0.3
CA F:PRO69 4.9 20.8 1.0
N F:ARG68 5.0 24.1 1.0
CA F:ARG68 5.0 21.6 1.0

Reference:

K.Michalska, C.Chang, N.I.Maltseva, R.Jedrzejczak, G.T.Robertson, F.Gusovsky, P.Mccarren, S.L.Schreiber, P.P.Nag, A.Joachimiak. Allosteric Inhibitors of Mycobacterium Tuberculosis Tryptophan Synthase. Protein Sci. V. 29 779 2020.
ISSN: ESSN 1469-896X
PubMed: 31930594
DOI: 10.1002/PRO.3825
Page generated: Tue Oct 8 14:08:03 2024

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