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Sodium in PDB 2qwp: Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2

Enzymatic activity of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2

All present enzymatic activity of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2, PDB code: 2qwp was solved by J.Jiang, E.G.Maes, L.Wang, A.B.Taylor, A.P.Hinck, E.M.Lafer, R.Sousa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.66 / 1.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 38.654, 58.641, 225.558, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 24.3

Other elements in 2qwp:

The structure of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2 (pdb code 2qwp). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2, PDB code: 2qwp:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 2qwp

Go back to Sodium Binding Sites List in 2qwp
Sodium binding site 1 out of 2 in the Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na489

b:23.3
occ:1.00
 O3B A:ADP487 2.7 25.7 1.0
O A:TYR15 2.7 25.5 1.0
OD2 A:ASP10 2.8 29.9 1.0
O A:HOH3183 2.9 17.2 1.0
O A:HOH3196 2.9 21.6 1.0
O3A A:ADP487 3.3 25.9 1.0
CG A:ASP10 3.4 27.1 1.0
PB A:ADP487 3.4 25.4 1.0
OD1 A:ASP10 3.5 29.3 1.0
O A:HOH3390 3.6 16.6 1.0
C A:TYR15 3.6 26.4 1.0
MG A:MG491 3.8 17.2 1.0
O1B A:ADP487 3.9 27.4 1.0
CA A:GLY12 3.9 25.7 1.0
PA A:ADP487 4.1 27.4 1.0
O1A A:ADP487 4.2 24.8 1.0
CB A:TYR15 4.3 26.5 1.0
O2A A:ADP487 4.3 25.7 1.0
N A:GLY12 4.3 26.1 1.0
N A:SER16 4.4 25.8 1.0
CA A:TYR15 4.4 26.0 1.0
CA A:SER16 4.4 25.9 1.0
CB A:ASP10 4.6 25.9 1.0
O A:HOH3153 4.6 16.2 1.0
N A:TYR15 4.7 25.9 1.0
O A:ASP366 4.7 18.9 1.0
O A:ASP10 4.7 25.6 1.0
O2B A:ADP487 4.8 27.7 1.0
C A:SER16 4.9 26.0 1.0
O A:HOH3388 5.0 18.5 1.0
C A:GLY12 5.0 26.2 1.0

Sodium binding site 2 out of 2 in 2qwp

Go back to Sodium Binding Sites List in 2qwp
Sodium binding site 2 out of 2 in the Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Disulfide-Bond-Crosslinked Complex of Bovine HSC70 (1-394AA)R171C and Bovine Auxilin (810-910AA)D876C in the Adp*Pi Form #2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na490

b:26.2
occ:1.00
 OG1 A:THR204 2.8 24.0 1.0
O4 A:PO4488 2.8 17.3 1.0
OD2 A:ASP206 3.0 28.4 1.0
OD1 A:ASP199 3.1 28.6 1.0
O A:THR204 3.2 24.4 1.0
O A:HOH3388 3.3 18.5 1.0
CG A:ASP199 3.5 26.0 1.0
O A:ASP199 3.6 26.8 1.0
P A:PO4488 3.7 17.3 1.0
C A:THR204 3.8 24.5 1.0
O3 A:PO4488 3.9 18.6 1.0
OD2 A:ASP199 3.9 27.6 1.0
O1 A:PO4488 4.0 17.2 1.0
CG A:ASP206 4.0 26.5 1.0
O A:HOH3180 4.0 16.6 1.0
N A:GLY201 4.0 25.6 1.0
CB A:THR204 4.0 24.4 1.0
MG A:MG491 4.0 17.2 1.0
C A:ASP199 4.2 26.4 1.0
O A:HOH3173 4.3 19.0 1.0
CB A:ASP199 4.3 25.9 1.0
N A:ASP206 4.3 24.5 1.0
O A:HOH3162 4.3 19.6 1.0
CA A:GLY201 4.4 25.0 1.0
N A:PHE205 4.4 25.0 1.0
O A:HOH3158 4.4 16.1 1.0
CA A:THR204 4.4 24.7 1.0
CB A:ASP206 4.5 26.0 1.0
CA A:PHE205 4.6 24.8 1.0
O2B A:ADP487 4.7 27.7 1.0
C A:PHE205 4.8 24.7 1.0
C A:LEU200 4.8 26.1 1.0
N A:THR204 4.9 24.1 1.0
N A:LEU200 4.9 26.2 1.0
CA A:ASP199 4.9 25.9 1.0
OD1 A:ASP206 4.9 26.4 1.0
OE1 A:GLU175 4.9 27.4 1.0
CA A:LEU200 5.0 26.0 1.0

Reference:

J.Jiang, E.G.Maes, A.B.Taylor, L.Wang, A.P.Hinck, E.M.Lafer, R.Sousa. Structural Basis of J Cochaperone Binding and Regulation of HSP70. Mol.Cell V. 28 422 2007.
ISSN: ISSN 1097-2765
PubMed: 17996706
DOI: 10.1016/J.MOLCEL.2007.08.022
Page generated: Mon Oct 7 04:05:51 2024

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