Sodium in PDB 2obv: Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product

All present enzymatic activity of Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product:
2.5.1.6;

The structure of Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product, PDB code: 2obv was solved by E.S.Pilka, N.Shafqat, K.L.Kavanagh, C.Cooper, V.Hozjan, A.Turnbull, F.Vondelft, C.H.Arrowsmith, A.Edwards, J.Weigelt, M.Sundstrom, U.Oppermann, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.05
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	66.404, 95.016, 115.773, 90.00, 90.00, 90.00
R / Rfree (%)	13.9 / 18.3

The binding sites of Sodium atom in the Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product (pdb code 2obv). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product, PDB code: 2obv:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product within 5.0Å range: probe atom residue distance (Å) B Occ A:Na401 b:44.3 occ:1.00 OD1 A:ASP166 3.1 27.7 1.0 O A:HOH681 3.7 20.2 1.0 CB A:ALA162 3.7 21.6 1.0 O A:ALA162 3.9 21.0 1.0 CG A:ASP166 4.0 25.1 1.0 CA A:ALA162 4.1 21.9 1.0 OD2 A:ASP166 4.2 26.2 1.0 CE2 A:TYR377 4.3 22.2 1.0 C A:ALA162 4.4 21.0 1.0 OH A:TYR377 4.4 25.5 1.0 CZ A:TYR377 4.4 23.6 1.0 O1 A:PG4602 4.9 40.8 1.0 OE2 A:GLU27 4.9 30.1 1.0 CD2 A:TYR377 4.9 23.6 1.0 CB A:ALA165 5.0 21.4 1.0

Sodium binding site 2 out of 2 in the Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product within 5.0Å range: probe atom residue distance (Å) B Occ A:Na402 b:48.8 occ:1.00 OE1 A:GLU216 2.9 19.5 1.0 OE2 A:GLU216 3.2 22.5 1.0 O A:HOH756 3.3 28.4 1.0 CD A:GLU216 3.5 22.0 1.0 CB A:THR214 4.3 22.4 1.0 CG2 A:THR214 4.5 22.1 1.0 CG A:GLU216 5.0 21.6 1.0

E.S.Pilka, N.Shafqat, K.L.Kavanagh, C.Cooper, V.Hozjan, A.Turnbull, F.Von Delft, C.H.Arrowsmith, A.Edwards, J.Weigelt, M.Sundstrom, U.Oppermann, Structural Genomics Consortium (Sgc). Crystal Structure of the Human S-Adenosylmethionine Synthetase 1 in Complex with the Product. To Be Published.