Sodium in PDB 2o12: Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn

All present enzymatic activity of Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn:
4.2.3.5;

The structure of Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn, PDB code: 2o12 was solved by M.Bruning, H.D.Bartunik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.74 / 1.72
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	133.445, 133.445, 158.619, 90.00, 90.00, 120.00
R / Rfree (%)	16.5 / 18.8

The binding sites of Sodium atom in the Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn (pdb code 2o12). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn, PDB code: 2o12:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn within 5.0Å range: probe atom residue distance (Å) B Occ A:Na598 b:28.6 occ:1.00 O A:HOH998 2.8 24.1 0.5 O A:HOH911 2.8 33.4 1.0 N A:ALA376 3.1 18.8 1.0 O A:HOH918 3.2 31.0 0.5 O A:HOH916 3.3 45.0 1.0 N A:LEU375 3.6 17.9 1.0 CB A:ALA376 3.6 24.3 1.0 CB A:SER374 3.8 21.8 1.0 CB A:LEU375 3.9 18.6 1.0 CA A:ALA376 4.0 20.4 1.0 CA A:LEU375 4.0 16.7 1.0 C A:LEU375 4.0 17.0 1.0 OG A:SER374 4.1 21.3 1.0 CA A:GLY25 4.1 19.6 1.0 O A:ALA24 4.1 18.7 1.0 C A:SER374 4.2 18.6 1.0 CA A:SER374 4.5 18.0 1.0 O A:HOH1022 4.6 30.7 0.5 O A:HOH917 4.6 22.9 0.5 C A:ALA24 4.8 18.8 1.0 O A:HOH912 4.8 32.9 1.0 O A:GLY25 4.8 21.4 1.0 C A:GLY25 4.9 19.4 1.0 N A:GLY25 4.9 19.3 1.0

Sodium binding site 2 out of 2 in the Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Mycobacterium Tuberculosis Chorismate Synthase in Complex with Fmn within 5.0Å range: probe atom residue distance (Å) B Occ A:Na599 b:29.2 occ:1.00 O A:HOH962 2.7 56.9 1.0 O A:HOH963 2.8 33.3 1.0 ND2 A:ASN293 3.0 20.3 1.0 CB A:ASN293 3.6 21.2 1.0 NE A:ARG309 3.7 26.6 1.0 CD A:ARG309 3.7 29.2 0.5 CG A:ASN293 3.8 20.7 1.0 CG A:PRO180 3.8 48.8 1.0 CG A:PRO307 3.9 24.2 1.0 CB A:PRO307 3.9 24.8 1.0 CD A:PRO307 4.2 23.9 1.0 CG A:ARG309 4.3 26.9 1.0 O A:HOH966 4.4 54.1 1.0 CD A:PRO180 4.5 47.7 1.0 CZ A:ARG309 4.8 27.6 1.0 O A:HOH964 4.9 37.5 1.0 O A:ASN293 4.9 21.1 1.0 O A:PRO307 4.9 20.3 1.0 CA A:ASN293 5.0 20.3 1.0

M.Bruning, G.P.Bourenkov, N.I.Strizhov, H.D.Bartunik. Complexes of Chorismate Synthase From M. Tuberculosis To Be Published.