Sodium in PDB 8qu7: Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34

The structure of Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34, PDB code: 8qu7 was solved by J.C.Maddumage, M.Kvansakul, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.45 / 2.60
Space group	I 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	71.651, 38.462, 227.355, 90, 90.18, 90
R / Rfree (%)	21.3 / 23.5

The binding sites of Sodium atom in the Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34 (pdb code 8qu7). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34, PDB code: 8qu7:

Sodium binding site 1 out of 1 in the Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Plasmodium Falciparum Apical Membrane Antigen (AMA1) in Complex with Single Domain I-Body WD34 within 5.0Å range: probe atom residue distance (Å) B Occ E:Na503 b:53.3 occ:1.00 HB2 E:TYR113 4.3 38.9 1.0 CZ3 E:TRP110 4.3 40.8 1.0 CE3 E:TRP110 4.4 37.9 1.0 O E:HOH639 4.4 44.2 1.0 HZ3 E:TRP110 4.5 44.0 1.0 HA E:TRP110 4.6 48.9 1.0 CH2 E:TRP110 4.6 41.7 1.0 HE3 E:TRP110 4.6 34.5 1.0 O E:PRO109 4.7 46.1 1.0 HB2 E:PRO109 4.7 45.8 1.0 CD2 E:TRP110 4.7 39.6 1.0 HD2 E:TYR113 4.8 36.8 1.0 HB3 E:TYR113 4.9 38.9 1.0 HH2 E:TRP110 4.9 42.4 1.0 CZ2 E:TRP110 4.9 40.5 1.0 CB E:TYR113 5.0 38.9 1.0 CE2 E:TRP110 5.0 39.5 1.0

M.Foley, D.Angage, R.Anders, J.Chmielewski, J.C.Maddumage, E.Hesping, S.Caiazzo, K.H.Lai, L.Yeoh, H.Opi, C.Cairns, J.Beeson, M.Kvansakul, D.Wilson, J.Boddey. A Broadly Cross-Reactive I-Body to AMA1 Potently Inhibits Blood and Liver Stages of Plasmodium Parasites Res Sq 2024.
ISSN: ESSN 2693-5015
DOI: 10.21203/RS.3.RS-3671797/V1