Sodium in PDB 8fhp: Cryo-Em Structure of Human Ncc (Class 3-1)

The structure of Cryo-Em Structure of Human Ncc (Class 3-1) also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of Human Ncc (Class 3-1) (pdb code 8fhp). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Human Ncc (Class 3-1), PDB code: 8fhp:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1102 b:41.5 occ:1.00 OG A:SER468 2.3 43.7 1.0 O A:ALA464 2.3 49.2 1.0 O A:LEU148 2.4 44.9 1.0 O A:TRP151 2.6 44.4 1.0 OG A:SER467 2.8 45.7 1.0 N A:SER468 3.3 43.7 1.0 C A:ALA464 3.3 49.2 1.0 CB A:SER468 3.4 43.7 1.0 C A:LEU148 3.6 44.9 1.0 CA A:ALA464 3.7 49.2 1.0 CA A:SER468 3.8 43.7 1.0 C A:TRP151 3.8 44.4 1.0 CB A:SER467 4.0 45.7 1.0 C A:SER467 4.1 45.7 1.0 CA A:LEU148 4.4 44.9 1.0 CB A:ALA464 4.4 49.2 1.0 N A:ASN149 4.4 46.0 1.0 N A:THR465 4.5 48.8 1.0 CA A:ASN149 4.5 46.0 1.0 CA A:SER467 4.5 45.7 1.0 O A:GLY463 4.6 49.9 1.0 CA A:GLY152 4.7 47.6 1.0 N A:GLY152 4.7 47.6 1.0 CA A:TRP151 4.7 44.4 1.0 N A:SER467 4.7 45.7 1.0 CB A:LEU148 4.8 44.9 1.0 C A:ASN149 4.8 46.0 1.0 CB A:TRP151 4.8 44.4 1.0 CA A:THR465 4.8 48.8 1.0 N A:TRP151 4.9 44.4 1.0 O A:ASN149 4.9 46.0 1.0 O A:SER467 5.0 45.7 1.0 N A:ALA464 5.0 49.2 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1102 b:41.8 occ:1.00 OG B:SER468 2.3 44.0 1.0 O B:LEU148 2.3 44.4 1.0 O B:ALA464 2.3 49.4 1.0 O B:TRP151 2.6 44.1 1.0 OG B:SER467 2.8 45.7 1.0 N B:SER468 3.3 44.0 1.0 C B:ALA464 3.3 49.4 1.0 CB B:SER468 3.4 44.0 1.0 C B:LEU148 3.6 44.4 1.0 CA B:ALA464 3.7 49.4 1.0 CA B:SER468 3.8 44.0 1.0 C B:TRP151 3.8 44.1 1.0 CB B:SER467 4.0 45.7 1.0 C B:SER467 4.1 45.7 1.0 N B:ASN149 4.4 46.0 1.0 CA B:ASN149 4.4 46.0 1.0 CA B:LEU148 4.4 44.4 1.0 CB B:ALA464 4.4 49.4 1.0 N B:THR465 4.5 49.4 1.0 CA B:SER467 4.5 45.7 1.0 O B:GLY463 4.6 49.9 1.0 CA B:GLY152 4.7 47.1 1.0 N B:GLY152 4.7 47.1 1.0 CA B:TRP151 4.7 44.1 1.0 N B:SER467 4.7 45.7 1.0 CB B:LEU148 4.8 44.4 1.0 C B:ASN149 4.8 46.0 1.0 CB B:TRP151 4.8 44.1 1.0 CA B:THR465 4.8 49.4 1.0 N B:TRP151 4.9 44.1 1.0 O B:SER467 5.0 45.7 1.0 N B:ALA464 5.0 49.4 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0