Sodium in PDB 8cv2: Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State

The binding sites of Sodium atom in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State (pdb code 8cv2). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State, PDB code: 8cv2:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6;

Sodium binding site 1 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na601 b:42.3 occ:1.00 OD2 A:ASP455 2.5 42.1 1.0 O A:ASN366 2.7 46.1 1.0 O A:GLY362 3.1 42.4 1.0 CG A:ASP455 3.4 42.8 1.0 CB A:ASN451 3.4 38.5 1.0 CA A:ALA363 3.6 38.5 1.0 OD1 A:ASP455 3.7 44.6 1.0 O A:ASN451 3.7 42.5 1.0 C A:ASN366 3.9 44.9 1.0 O A:ALA363 3.9 43.5 1.0 C A:ASN451 3.9 38.7 1.0 C A:GLY362 3.9 38.4 1.0 C A:ALA363 4.1 40.7 1.0 CA A:ASN451 4.1 37.4 1.0 CE A:MET367 4.1 46.6 1.0 N A:ALA363 4.2 37.8 1.0 CB A:ASN366 4.3 42.9 1.0 SD A:MET367 4.3 60.0 1.0 CG A:ASN451 4.4 41.1 1.0 CB A:SER333 4.4 43.4 1.0 CA A:ASN366 4.5 44.0 1.0 N A:VAL452 4.5 39.0 1.0 OG A:SER333 4.6 47.2 1.0 N A:ASN366 4.7 44.2 1.0 ND2 A:ASN451 4.8 39.7 1.0 CB A:ALA363 4.8 37.4 1.0 CB A:ASP455 4.8 40.1 1.0 N A:MET367 5.0 45.6 1.0

Sodium binding site 2 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:44.3 occ:1.00 OD1 A:ASP368 2.3 50.4 1.0 OG1 A:THR101 2.3 41.3 1.0 OG1 A:THR102 2.3 44.6 1.0 OD1 A:ASN366 2.3 45.5 1.0 O A:TYR98 2.3 42.5 1.0 N A:THR102 2.6 43.8 1.0 CB A:THR101 3.3 40.2 1.0 CA A:THR102 3.3 43.3 1.0 CG A:ASP368 3.3 48.2 1.0 CB A:THR102 3.3 43.9 1.0 C A:THR101 3.3 42.8 1.0 C A:TYR98 3.3 38.7 1.0 CG A:ASN366 3.5 43.2 1.0 OD2 A:ASP368 3.5 47.3 1.0 CA A:THR101 3.7 41.1 1.0 CA A:TYR98 3.7 35.1 1.0 ND2 A:ASN366 4.0 41.9 1.0 N A:THR101 4.1 41.2 1.0 O A:THR101 4.2 44.2 1.0 CB A:TYR98 4.4 35.1 1.0 O A:TYR97 4.5 38.9 1.0 CG2 A:THR102 4.5 48.2 1.0 N A:PHE99 4.6 39.5 1.0 CG2 A:THR101 4.6 37.4 1.0 CB A:ASP368 4.6 46.1 1.0 CB A:ASN366 4.7 42.9 1.0 C A:THR102 4.8 46.4 1.0 CA A:ASN366 4.8 44.0 1.0 N A:ASP368 4.8 43.5 1.0 N A:MET367 4.9 45.6 1.0 C A:PHE99 4.9 40.0 1.0 CA A:ASP368 4.9 44.4 1.0 N A:TYR98 4.9 33.9 1.0 O A:PHE99 4.9 43.2 1.0 CA A:PHE99 5.0 39.2 1.0

Sodium binding site 3 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ B:Na601 b:42.3 occ:1.00 OD2 B:ASP455 2.5 42.1 1.0 O B:ASN366 2.7 46.1 1.0 O B:GLY362 3.1 42.4 1.0 CG B:ASP455 3.4 42.8 1.0 CB B:ASN451 3.4 38.5 1.0 CA B:ALA363 3.6 38.5 1.0 OD1 B:ASP455 3.7 44.6 1.0 O B:ASN451 3.7 42.5 1.0 C B:ASN366 3.9 44.9 1.0 O B:ALA363 3.9 43.5 1.0 C B:ASN451 3.9 38.7 1.0 C B:GLY362 3.9 38.4 1.0 C B:ALA363 4.1 40.7 1.0 CA B:ASN451 4.1 37.4 1.0 CE B:MET367 4.1 46.6 1.0 N B:ALA363 4.2 37.8 1.0 CB B:ASN366 4.3 42.9 1.0 SD B:MET367 4.3 60.0 1.0 CG B:ASN451 4.4 41.1 1.0 CB B:SER333 4.4 43.4 1.0 CA B:ASN366 4.5 44.0 1.0 N B:VAL452 4.5 39.0 1.0 OG B:SER333 4.6 47.2 1.0 N B:ASN366 4.7 44.2 1.0 ND2 B:ASN451 4.8 39.7 1.0 CB B:ALA363 4.8 37.4 1.0 CB B:ASP455 4.8 40.1 1.0 N B:MET367 5.0 45.6 1.0

Sodium binding site 4 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ B:Na602 b:44.3 occ:1.00 OD1 B:ASP368 2.3 50.4 1.0 OG1 B:THR101 2.3 41.3 1.0 OG1 B:THR102 2.3 44.6 1.0 OD1 B:ASN366 2.3 45.5 1.0 O B:TYR98 2.3 42.5 1.0 N B:THR102 2.6 43.8 1.0 CB B:THR101 3.3 40.2 1.0 CA B:THR102 3.3 43.3 1.0 CG B:ASP368 3.3 48.2 1.0 CB B:THR102 3.3 43.9 1.0 C B:THR101 3.3 42.8 1.0 C B:TYR98 3.3 38.7 1.0 CG B:ASN366 3.5 43.2 1.0 OD2 B:ASP368 3.5 47.3 1.0 CA B:THR101 3.7 41.1 1.0 CA B:TYR98 3.7 35.1 1.0 ND2 B:ASN366 4.0 41.9 1.0 N B:THR101 4.1 41.2 1.0 O B:THR101 4.2 44.2 1.0 CB B:TYR98 4.4 35.1 1.0 O B:TYR97 4.5 38.9 1.0 CG2 B:THR102 4.5 48.2 1.0 N B:PHE99 4.6 39.5 1.0 CG2 B:THR101 4.6 37.4 1.0 CB B:ASP368 4.6 46.1 1.0 CB B:ASN366 4.7 42.9 1.0 C B:THR102 4.8 46.4 1.0 CA B:ASN366 4.8 44.0 1.0 N B:ASP368 4.8 43.5 1.0 N B:MET367 4.9 45.6 1.0 C B:PHE99 4.9 40.0 1.0 N B:TYR98 4.9 33.9 1.0 CA B:ASP368 4.9 44.4 1.0 O B:PHE99 4.9 43.2 1.0 CA B:PHE99 5.0 39.2 1.0

Sodium binding site 5 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ C:Na601 b:42.3 occ:1.00 OD2 C:ASP455 2.5 42.1 1.0 O C:ASN366 2.7 46.1 1.0 O C:GLY362 3.1 42.4 1.0 CG C:ASP455 3.4 42.8 1.0 CB C:ASN451 3.4 38.5 1.0 CA C:ALA363 3.6 38.5 1.0 OD1 C:ASP455 3.7 44.6 1.0 O C:ASN451 3.7 42.5 1.0 C C:ASN366 3.9 44.9 1.0 O C:ALA363 3.9 43.5 1.0 C C:ASN451 3.9 38.7 1.0 C C:GLY362 3.9 38.4 1.0 C C:ALA363 4.1 40.7 1.0 CA C:ASN451 4.1 37.4 1.0 CE C:MET367 4.1 46.6 1.0 N C:ALA363 4.2 37.8 1.0 CB C:ASN366 4.3 42.9 1.0 SD C:MET367 4.3 60.0 1.0 CG C:ASN451 4.4 41.1 1.0 CB C:SER333 4.4 43.4 1.0 CA C:ASN366 4.5 44.0 1.0 N C:VAL452 4.5 39.0 1.0 OG C:SER333 4.6 47.2 1.0 N C:ASN366 4.7 44.2 1.0 ND2 C:ASN451 4.8 39.7 1.0 CB C:ALA363 4.8 37.4 1.0 CB C:ASP455 4.8 40.1 1.0 N C:MET367 5.0 45.6 1.0

Sodium binding site 6 out of 6 in the Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of Human Excitatory Amino Acid Transporter 3 (EAAT3) in An Outward Facing Sodium-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ C:Na602 b:44.3 occ:1.00 OD1 C:ASP368 2.3 50.4 1.0 OG1 C:THR101 2.3 41.3 1.0 OG1 C:THR102 2.3 44.6 1.0 O C:TYR98 2.3 42.5 1.0 OD1 C:ASN366 2.3 45.5 1.0 N C:THR102 2.6 43.8 1.0 CB C:THR101 3.3 40.2 1.0 CA C:THR102 3.3 43.3 1.0 CG C:ASP368 3.3 48.2 1.0 CB C:THR102 3.3 43.9 1.0 C C:THR101 3.3 42.8 1.0 C C:TYR98 3.3 38.7 1.0 CG C:ASN366 3.5 43.2 1.0 OD2 C:ASP368 3.5 47.3 1.0 CA C:THR101 3.7 41.1 1.0 CA C:TYR98 3.7 35.1 1.0 ND2 C:ASN366 4.0 41.9 1.0 N C:THR101 4.1 41.2 1.0 O C:THR101 4.2 44.2 1.0 CB C:TYR98 4.4 35.1 1.0 O C:TYR97 4.5 38.9 1.0 CG2 C:THR102 4.5 48.2 1.0 N C:PHE99 4.6 39.5 1.0 CG2 C:THR101 4.6 37.4 1.0 CB C:ASP368 4.6 46.1 1.0 CB C:ASN366 4.7 42.9 1.0 C C:THR102 4.8 46.4 1.0 CA C:ASN366 4.8 44.0 1.0 N C:ASP368 4.8 43.5 1.0 N C:MET367 4.9 45.6 1.0 C C:PHE99 4.9 40.0 1.0 CA C:ASP368 4.9 44.4 1.0 N C:TYR98 4.9 33.9 1.0 O C:PHE99 4.9 43.2 1.0 CA C:PHE99 5.0 39.2 1.0

B.Qiu, O.Boudker. Symport and Antiport Mechanisms of Human Glutamate Transporters Nat Commun 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-38120-5