Sodium in PDB 7zso: Human Purine Nucleoside Phosphorylase in Complex with Js-554

All present enzymatic activity of Human Purine Nucleoside Phosphorylase in Complex with Js-554:
2.4.2.1;

The structure of Human Purine Nucleoside Phosphorylase in Complex with Js-554, PDB code: 7zso was solved by S.Djukic, P.Pachl, P.Rezacova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.81 / 1.95
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	58.48, 119.33, 130.18, 90, 90, 90
R / Rfree (%)	21.6 / 26.2

The structure of Human Purine Nucleoside Phosphorylase in Complex with Js-554 also contains other interesting chemical elements:

Fluorine

(F)

15 atoms

The binding sites of Sodium atom in the Human Purine Nucleoside Phosphorylase in Complex with Js-554 (pdb code 7zso). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Purine Nucleoside Phosphorylase in Complex with Js-554, PDB code: 7zso:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Human Purine Nucleoside Phosphorylase in Complex with Js-554


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Purine Nucleoside Phosphorylase in Complex with Js-554 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na311 b:41.2 occ:1.00 O2 B:SO4303 2.3 86.9 1.0 S B:SO4303 3.7 99.2 1.0 O1 B:SO4303 4.2 77.0 1.0 O3 B:SO4303 4.2 79.5 1.0 CD2 B:LEU138 4.4 25.6 1.0 CD2 A:LEU138 4.4 22.9 1.0 CD2 C:LEU138 4.5 24.9 1.0 O4 B:SO4303 4.6 71.0 1.0 CD1 B:LEU212 4.7 32.4 1.0 CD1 A:LEU212 4.9 32.4 1.0

Sodium binding site 2 out of 2 in the Human Purine Nucleoside Phosphorylase in Complex with Js-554


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human Purine Nucleoside Phosphorylase in Complex with Js-554 within 5.0Å range: probe atom residue distance (Å) B Occ C:Na311 b:59.2 occ:1.00 O2 C:SO4306 3.0 73.0 1.0 NH2 C:ARG173 3.8 34.2 1.0 S C:SO4306 4.4 76.1 1.0 O4 C:SO4306 4.6 81.6 1.0

J.Skacel, S.Djukic. Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Pnp Inhibitors To Be Published.