Sodium in PDB 7l4l: Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp

All present enzymatic activity of Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp:
2.3.1.179;

The structure of Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp, PDB code: 7l4l was solved by J.T.Mindrebo, A.Chen, W.E.Kim, M.D.Burkart, J.P.Noel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.40 / 2.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	83.782, 92.136, 113.746, 90, 90, 90
R / Rfree (%)	22.2 / 26.7

The binding sites of Sodium atom in the Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp (pdb code 7l4l). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp, PDB code: 7l4l:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp within 5.0Å range: probe atom residue distance (Å) B Occ A:Na501 b:22.0 occ:1.00 OE1 A:GLU349 2.4 35.7 1.0 O A:ASN301 2.5 40.7 1.0 O A:ASN396 2.7 34.7 1.0 OD1 A:ASN301 2.8 35.2 1.0 O A:ALA302 2.9 33.4 1.0 C A:ALA302 3.3 32.7 1.0 C A:ASN301 3.4 39.1 1.0 CD A:GLU349 3.5 36.4 1.0 N A:ASN396 3.5 36.9 1.0 SG A:CYS395 3.6 47.0 1.0 C A:ASN396 3.7 36.2 1.0 N A:HIS303 3.7 32.1 1.0 CG A:ASN301 3.8 33.8 1.0 CB A:GLU349 3.9 30.7 1.0 CA A:HIS303 3.9 35.8 1.0 CB A:ASN301 4.1 35.0 1.0 N A:ALA302 4.1 41.0 1.0 CA A:ASN396 4.1 41.3 1.0 CA A:ALA302 4.1 35.1 1.0 CG A:GLU349 4.2 36.0 1.0 CA A:ASN301 4.4 35.6 1.0 C A:CYS395 4.4 37.6 1.0 OE2 A:GLU349 4.5 34.9 1.0 CA A:CYS395 4.5 38.6 1.0 CB A:ASN396 4.6 37.4 1.0 NZ A:LYS335 4.6 28.2 1.0 CB A:CYS395 4.7 42.2 1.0 OG A:SER397 4.8 37.3 1.0 ND1 A:HIS303 4.8 28.4 1.0 CB A:HIS303 4.9 36.4 1.0 N A:SER397 4.9 33.9 1.0 C A:HIS303 4.9 37.3 1.0 ND2 A:ASN301 5.0 33.9 1.0

Sodium binding site 2 out of 2 in the Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, Fabf, and C8-Crypto Acyl Carrier Protein, Acpp within 5.0Å range: probe atom residue distance (Å) B Occ B:Na501 b:29.0 occ:1.00 OE1 B:GLU349 2.4 44.4 1.0 O B:ASN301 2.4 53.6 1.0 O B:ASN396 2.7 43.0 1.0 OD1 B:ASN301 2.9 46.6 1.0 SG B:CYS395 3.1 43.9 1.0 O B:ALA302 3.3 51.1 1.0 N B:ASN396 3.4 45.3 1.0 C B:ASN301 3.5 53.2 1.0 CD B:GLU349 3.5 43.5 1.0 C B:ALA302 3.7 49.4 1.0 CB B:GLU349 3.7 43.8 1.0 C B:ASN396 3.7 42.9 1.0 CG B:ASN301 3.8 47.6 1.0 CB B:ASN301 4.0 48.9 1.0 CA B:ASN396 4.1 48.9 1.0 N B:HIS303 4.1 49.4 1.0 CG B:GLU349 4.2 42.9 1.0 C B:CYS395 4.2 45.5 1.0 CA B:CYS395 4.3 46.5 1.0 N B:ALA302 4.3 54.3 1.0 CB B:CYS395 4.3 45.4 1.0 CA B:HIS303 4.3 51.4 1.0 CA B:ASN301 4.3 50.5 1.0 CA B:ALA302 4.4 52.6 1.0 OE2 B:GLU349 4.5 43.2 1.0 CB B:ASN396 4.7 50.0 1.0 OG B:SER397 4.8 44.4 1.0 NZ B:LYS335 4.8 44.7 1.0 N B:SER397 4.9 41.8 1.0

J.T.Mindrebo, A.Chen, W.E.Kim, R.N.Re, T.D.Davis, J.P.Noel, M.D.Burkart. Structure and Mechanistic Analyses of the Gating Mechanism of Elongating Ketosynthases Acs Catalysis V. 11 6787 2021.
ISSN: ESSN 2155-5435
DOI: 10.1021/ACSCATAL.1C00745