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Sodium in PDB 7kia: Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19Enzymatic activity of Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19
All present enzymatic activity of Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19, PDB code: 7kia
was solved by
J.Ke,
A.S.Wibowo,
J.J.Carter,
N.A.Larsen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19
(pdb code 7kia). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19, PDB code: 7kia: Jump to Sodium binding site number: 1; 2; Sodium binding site 1 out of 2 in 7kiaGo back to Sodium Binding Sites List in 7kia
Sodium binding site 1 out
of 2 in the Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19
Mono view Stereo pair view
Sodium binding site 2 out of 2 in 7kiaGo back to Sodium Binding Sites List in 7kia
Sodium binding site 2 out
of 2 in the Crystal Structure of FGFR2 Kinase Domain Gatekeeper Mutant V564F in Complex with Covalent Compound 19
Mono view Stereo pair view
Reference:
R.A.Brawn,
A.Cook,
K.Omoto,
J.Ke,
C.Karr,
F.Colombo,
M.Virrankoski,
S.Prajapati,
D.Reynolds,
D.M.Bolduc,
T.V.Nguyen,
P.Gee,
D.Borrelli,
B.Caleb,
S.Yao,
S.Irwin,
N.A.Larsen,
A.Selvaraj,
X.Zhao,
S.Ioannidis.
Discovery of Aminopyrazole Derivatives As Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3. Acs Med.Chem.Lett. V. 12 93 2021.
Page generated: Wed Mar 3 15:35:28 2021
ISSN: ISSN 1948-5875 PubMed: 33488969 DOI: 10.1021/ACSMEDCHEMLETT.0C00517 |
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