Atomistry » Sodium » PDB 7app-7b4w » 7awq
Atomistry »
  Sodium »
    PDB 7app-7b4w »
      7awq »

Sodium in PDB 7awq: Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101

Protein crystallography data

The structure of Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101, PDB code: 7awq was solved by J.C.Canul-Tec, P.Legrand, N.Reyes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.00 / 3.65
Space group P 63
Cell size a, b, c (Å), α, β, γ (°) 124, 124, 90.81, 90, 90, 120
R / Rfree (%) 23.3 / 27.1

Other elements in 7awq:

The structure of Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101 also contains other interesting chemical elements:

Barium (Ba) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101 (pdb code 7awq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101, PDB code: 7awq:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 7awq

Go back to Sodium Binding Sites List in 7awq
Sodium binding site 1 out of 2 in the Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na601

b:107.3
occ:1.00
OG1 A:THR130 2.2 92.9 1.0
O A:TYR127 2.2 89.1 1.0
OD1 A:ASN378 2.3 94.9 1.0
OG1 A:THR131 2.6 84.8 1.0
OD1 A:ASP380 2.8 100.7 1.0
C A:TYR127 3.0 89.6 1.0
CA A:TYR127 3.1 81.8 1.0
CG A:ASN378 3.3 97.2 1.0
N A:THR131 3.3 90.9 1.0
CB A:THR130 3.4 99.0 1.0
CB A:THR131 3.7 90.3 1.0
C A:THR130 3.8 97.8 1.0
CG A:ASP380 3.9 98.1 1.0
O A:TYR126 3.9 97.2 1.0
CA A:THR130 3.9 96.6 1.0
CA A:THR131 4.0 88.1 1.0
CB A:TYR127 4.0 77.5 1.0
ND2 A:ASN378 4.1 89.4 1.0
CB A:ASN378 4.1 67.8 1.0
N A:THR130 4.2 99.1 1.0
N A:TYR127 4.2 86.8 1.0
OD2 A:ASP380 4.3 103.5 1.0
CA A:ASN378 4.3 64.2 1.0
N A:MET128 4.3 90.2 1.0
CD1 A:TYR127 4.4 75.8 1.0
C A:TYR126 4.5 95.7 1.0
O A:THR130 4.6 99.0 1.0
CG2 A:THR130 4.6 101.6 1.0
CG A:TYR127 4.7 74.9 1.0
C A:ASN378 4.9 67.7 1.0
CG2 A:THR131 5.0 86.8 1.0

Sodium binding site 2 out of 2 in 7awq

Go back to Sodium Binding Sites List in 7awq
Sodium binding site 2 out of 2 in the Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Structure of the Thermostabilized EAAT1 Cryst-E386Q Mutant in Complex with L-Asp, Sodium Ions and the Allosteric Inhibitor UCPH101 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na602

b:41.9
occ:1.00
O A:THR376 2.2 48.4 1.0
CE A:MET379 2.3 55.2 1.0
O A:ALA420 2.3 49.3 1.0
O A:SER417 2.8 58.0 1.0
SD A:MET379 2.9 63.2 1.0
C A:THR376 3.0 48.4 1.0
C A:ALA420 3.4 48.7 1.0
CG A:MET379 3.5 63.1 1.0
O A:ILE418 3.5 53.4 1.0
N A:ILE377 3.7 47.8 1.0
CA A:THR376 3.9 41.2 1.0
CA A:ILE377 3.9 52.2 1.0
O A:ILE377 3.9 64.9 1.0
C A:ILE418 3.9 57.5 1.0
C A:SER417 3.9 62.2 1.0
CA A:ALA420 4.1 47.9 1.0
N A:ALA420 4.1 50.5 1.0
C A:ILE377 4.1 61.8 1.0
CB A:MET379 4.2 64.5 1.0
CA A:ILE418 4.3 57.2 1.0
C A:GLY419 4.3 52.2 1.0
CB A:ALA420 4.4 51.9 1.0
N A:ALA421 4.5 41.2 1.0
O A:GLY419 4.5 48.0 1.0
OG1 A:THR376 4.5 50.1 1.0
N A:ILE418 4.6 60.1 1.0
N A:GLY419 4.6 55.5 1.0
CA A:ALA421 4.8 37.1 1.0
C A:ALA421 4.8 41.6 1.0
O A:ALA375 4.8 43.5 1.0
CB A:THR376 4.9 48.2 1.0
N A:THR376 4.9 42.2 1.0

Reference:

J.Canul-Tec, J.Dhenin, R.Assal, P.Legrand, R.Martial, J.Chamot-Rooke, N.Reyes. Ion-Coupling Mechanism of Excitatory Amino Acid Transporters To Be Published.
Page generated: Tue Oct 8 16:03:54 2024

Last articles

Zn in 9FS1
Zn in 9FS3
Zn in 9FS2
Zn in 9H3H
Zn in 9F29
Zn in 9F2A
Zn in 9EY2
Zn in 9F26
Zn in 9E8J
Zn in 9E8N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy