Sodium in PDB 7auw: Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B.

All present enzymatic activity of Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B.:
3.4.24.63;

The structure of Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B., PDB code: 7auw was solved by U.Eckhard, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	76.26 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	126.66, 88.24, 156.66, 90, 113.82, 90
R / Rfree (%)	23.6 / 26.1

The structure of Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B. also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Sodium atom in the Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B. (pdb code 7auw). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B., PDB code: 7auw:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B.


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B. within 5.0Å range: probe atom residue distance (Å) B Occ A:Na701 b:92.2 occ:1.00 O A:SER266 2.4 99.5 1.0 OD1 A:ASP418 2.4 97.7 1.0 O A:PHE310 2.4 110.4 1.0 OD2 A:ASP418 2.4 101.1 1.0 OD1 A:ASP298 2.4 116.8 1.0 OG A:SER300 2.4 119.9 1.0 OE2 A:GLU268 2.4 128.3 1.0 CG A:ASP418 2.7 97.9 1.0 CG A:ASP298 3.4 116.4 1.0 CD A:GLU268 3.4 126.4 1.0 CB A:SER300 3.4 117.3 1.0 C A:SER266 3.5 99.9 1.0 C A:PHE310 3.6 110.5 1.0 CB A:ASP298 3.7 113.0 1.0 OE1 A:GLU268 4.0 130.4 1.0 N A:PHE310 4.0 116.8 1.0 N A:SER300 4.0 113.8 1.0 CA A:SER266 4.1 99.4 1.0 CB A:SER266 4.1 100.0 1.0 CB A:ASP418 4.2 92.7 1.0 CA A:SER300 4.3 116.1 1.0 OD1 A:ASP419 4.4 96.7 1.0 CA A:PHE310 4.4 113.5 1.0 CG A:GLU268 4.5 115.8 1.0 OD2 A:ASP298 4.6 117.9 1.0 C A:GLY309 4.6 120.5 1.0 N A:HIS299 4.6 111.2 1.0 N A:PHE311 4.6 108.0 1.0 N A:PHE267 4.7 100.5 1.0 CB A:PHE311 4.8 104.2 1.0 CA A:GLY309 4.8 124.1 1.0 CA A:PHE311 4.8 105.9 1.0 OG A:SER266 4.9 100.6 1.0 CB A:PHE267 4.9 100.1 1.0 CA A:ASP298 5.0 111.5 1.0

Sodium binding site 2 out of 2 in the Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B.


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Inhibitory Complex of Human Meprin Beta with Mouse Fetuin-B. within 5.0Å range: probe atom residue distance (Å) B Occ C:Na701 b:97.0 occ:1.00 O C:SER266 2.4 99.5 1.0 OG C:SER300 2.4 113.9 1.0 OD1 C:ASP418 2.4 102.4 1.0 O C:PHE310 2.4 108.5 1.0 OD1 C:ASP298 2.4 118.4 1.0 OD2 C:ASP418 2.4 103.7 1.0 OE2 C:GLU268 2.4 120.2 1.0 CG C:ASP418 2.7 101.1 1.0 CG C:ASP298 3.4 117.4 1.0 CB C:SER300 3.4 112.7 1.0 CD C:GLU268 3.5 119.0 1.0 C C:SER266 3.5 99.5 1.0 C C:PHE310 3.6 108.8 1.0 CB C:ASP298 3.7 112.3 1.0 OE1 C:GLU268 4.0 120.8 1.0 N C:PHE310 4.0 114.9 1.0 N C:SER300 4.0 110.9 1.0 CA C:SER266 4.1 99.5 1.0 CB C:SER266 4.1 101.0 1.0 CB C:ASP418 4.2 94.8 1.0 OD1 C:ASP419 4.3 96.9 1.0 CA C:SER300 4.4 112.4 1.0 CA C:PHE310 4.4 112.0 1.0 OD2 C:ASP298 4.5 119.1 1.0 N C:HIS299 4.6 108.9 1.0 N C:PHE311 4.6 106.5 1.0 C C:GLY309 4.6 118.2 1.0 N C:PHE267 4.7 99.3 1.0 CB C:PHE311 4.8 103.5 1.0 CA C:PHE311 4.8 104.6 1.0 CG C:GLU268 4.8 111.9 1.0 CA C:GLY309 4.9 122.0 1.0 CB C:PHE267 4.9 98.4 1.0 CA C:ASP298 4.9 110.0 1.0

U.Eckhard, H.Korschgen, N.Von Wiegen, W.Stocker, F.X.Gomis-Ruth. The Crystal Structure of A 250-kDa Heterotetrameric Particle Explains Inhibition of Sheddase Meprin Beta By Endogenous Fetuin-B. Proc.Natl.Acad.Sci.Usa V. 118 2021.
ISSN: ESSN 1091-6490
PubMed: 33782129
DOI: 10.1073/PNAS.2023839118