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Sodium in PDB 6ze8: Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01Enzymatic activity of Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
All present enzymatic activity of Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01:
3.2.1.14; Protein crystallography data
The structure of Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01, PDB code: 6ze8
was solved by
M.Nowotny,
A.Bartlomiejczak,
A.Napiorkowska-Gromadzka,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ze8:
The structure of Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01 also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
(pdb code 6ze8). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01, PDB code: 6ze8: Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6; Sodium binding site 1 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 1 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Sodium binding site 2 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 2 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Sodium binding site 3 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 3 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Sodium binding site 4 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 4 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Sodium binding site 5 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 5 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Sodium binding site 6 out of 6 in 6ze8Go back to Sodium Binding Sites List in 6ze8
Sodium binding site 6 out
of 6 in the Crystal Structure of Human Chitotriosidase-1 (Hchit) Catalytic Domain in Complex with Compound Oatd-01
Mono view Stereo pair view
Reference:
R.Koralewski,
B.Dymek,
M.Mazur,
P.Sklepkiewicz,
S.Olejniczak,
W.Czestkowski,
K.Matyszewski,
G.Andryianau,
P.Niedziejko,
M.Kowalski,
M.Gruza,
B.Borek,
K.Jedrzejczak,
A.Bartoszewicz,
E.Pluta,
A.Rymaszewska,
M.Kania,
T.Rejczak,
S.Piasecka,
M.Mlacki,
M.Mazurkiewicz,
M.Piotrowicz,
M.Salamon,
A.Zagozdzon,
A.Napiorkowska-Gromadzka,
A.Bartlomiejczak,
W.Mozga,
P.Dobrzanski,
K.Dzwonek,
J.Golab,
M.Nowotny,
J.Olczak,
A.Golebiowski.
Discovery of Oatd-01 , A First-in-Class Chitinase Inhibitor As Potential New Therapeutics For Idiopathic Pulmonary Fibrosis. J.Med.Chem. 2020.
Page generated: Tue Dec 15 17:00:18 2020
ISSN: ISSN 0022-2623 PubMed: 33078933 DOI: 10.1021/ACS.JMEDCHEM.0C01179 |
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