Sodium in PDB 6z8c: Full Length Mutant Sodium Channel Navms in Complex with Compound 4

The structure of Full Length Mutant Sodium Channel Navms in Complex with Compound 4, PDB code: 6z8c was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.51 / 3.20
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	109.221, 109.221, 211.161, 90, 90, 90
R / Rfree (%)	25.4 / 26.6

The binding sites of Sodium atom in the Full Length Mutant Sodium Channel Navms in Complex with Compound 4 (pdb code 6z8c). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Full Length Mutant Sodium Channel Navms in Complex with Compound 4, PDB code: 6z8c:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in the Full Length Mutant Sodium Channel Navms in Complex with Compound 4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Full Length Mutant Sodium Channel Navms in Complex with Compound 4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na301 b:37.5 occ:0.25 NA A:NA302 4.5 69.1 0.2 O A:LEU177 4.8 39.3 1.0 O A:THR176 5.0 39.9 1.0

Sodium binding site 2 out of 3 in the Full Length Mutant Sodium Channel Navms in Complex with Compound 4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Full Length Mutant Sodium Channel Navms in Complex with Compound 4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na302 b:69.1 occ:0.25 NA A:NA303 4.3 86.5 0.2 NA A:NA301 4.5 37.5 0.2 OE2 A:GLU178 4.5 56.0 1.0 N A:SER179 4.6 37.8 1.0 OG A:SER179 4.9 42.4 1.0

Sodium binding site 3 out of 3 in the Full Length Mutant Sodium Channel Navms in Complex with Compound 4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Full Length Mutant Sodium Channel Navms in Complex with Compound 4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na303 b:86.5 occ:0.25 OG A:SER179 4.0 42.4 1.0 NA A:NA302 4.3 69.1 0.2

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048