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Sodium in PDB 6xpb: Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule

Enzymatic activity of Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule

All present enzymatic activity of Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule:
2.3.2.2; 3.4.19.13; 3.4.19.14;

Protein crystallography data

The structure of Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule, PDB code: 6xpb was solved by S.S.Terzyan, M.H.Hanigan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.37 / 1.74
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 106.362, 124.218, 104.232, 90.00, 90.00, 90.00
R / Rfree (%) 15.3 / 18.9

Other elements in 6xpb:

The structure of Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule (pdb code 6xpb). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule, PDB code: 6xpb:

Sodium binding site 1 out of 1 in 6xpb

Go back to Sodium Binding Sites List in 6xpb
Sodium binding site 1 out of 1 in the Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Human GGT1 in Complex with 2-Amino-4-(((1- ((Carboxymethyl)Amino)-1-Oxobutan-2-Yl)Oxy)(Phenoxy)Phosphoryl) Butanoic Acid (Acpb) Molecule within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na601

b:33.5
occ:1.00
 O B:HOH1303 2.7 16.2 1.0
CD2 A:HIS36 2.9 29.4 1.0
O B:ALA556 2.9 14.7 1.0
O A:HOH1045 3.2 42.9 1.0
O A:HOH702 3.3 29.4 1.0
O A:HOH991 3.4 50.5 1.0
CD B:LYS496 3.6 19.1 1.0
CG A:HIS36 3.6 30.5 1.0
CA B:ALA557 3.8 13.8 1.0
CB A:HIS36 3.9 28.6 1.0
O A:ASN35 3.9 43.0 1.0
NE2 A:HIS36 3.9 32.3 1.0
C B:ALA556 4.0 15.1 1.0
CB B:ALA557 4.0 15.1 1.0
CG B:LYS496 4.1 18.5 1.0
CE B:LYS496 4.1 19.9 1.0
CB B:LYS496 4.1 16.9 1.0
C A:ASN35 4.2 39.9 1.0
N B:ALA557 4.3 14.0 1.0
O A:HOH976 4.4 48.4 1.0
CA A:ASN35 4.4 43.6 1.0
CG B:PRO566 4.4 19.2 1.0
NZ B:LYS496 4.5 18.3 1.0
CD B:PRO566 4.7 16.1 1.0
N A:HIS36 4.7 35.3 1.0
OE1 B:GLU565 4.8 19.8 0.5
ND1 A:HIS36 4.8 34.9 1.0
N B:SER558 4.8 14.0 1.0
N A:ASN35 4.8 44.0 1.0
C B:ALA557 4.9 14.4 1.0
CA A:HIS36 4.9 29.6 1.0
CE1 A:HIS36 4.9 34.2 1.0
CA B:LYS496 5.0 16.4 1.0

Reference:

S.S.Terzyan, L.T.Nguyen, A.W.G.Burgett, A.Heroux, C.A.Smith, Y.You, M.H.Hanigan. Crystal Structures of Glutathione- and Inhibitor-Bound Human GGT1: Critical Interactions Within the Cysteinylglycine Binding Site. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 33187988
DOI: 10.1074/JBC.RA120.016265
Page generated: Tue Oct 8 14:53:14 2024

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