Sodium in PDB 6xev: Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2

The structure of Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 also contains other interesting chemical elements:

Potassium

(K)

13 atoms

The binding sites of Sodium atom in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 (pdb code 6xev). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2, PDB code: 6xev:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na414 b:84.8 occ:1.00 O A:SER232 2.7 96.3 1.0 O A:ARG230 2.8 96.3 1.0 OD2 A:ASP228 3.0 80.9 1.0 CG A:ASP228 3.8 80.9 1.0 C A:ARG230 3.8 96.3 1.0 C A:SER232 3.9 96.3 1.0 CB A:ASP228 4.2 80.9 1.0 C A:ASN231 4.3 96.3 1.0 N A:SER232 4.3 96.3 1.0 O A:LEU275 4.4 96.3 1.0 ND1 A:HIS233 4.4 96.3 1.0 CA A:ASN231 4.4 96.3 1.0 O A:VAL276 4.5 96.3 1.0 N A:ASN231 4.6 96.3 1.0 NE2 M:HIS69 4.6 107.6 1.0 O A:ASN231 4.7 96.3 1.0 CA A:HIS233 4.7 96.3 1.0 N A:HIS233 4.7 96.3 1.0 OD1 A:ASP228 4.7 80.9 1.0 CE1 A:HIS233 4.7 96.3 1.0 N A:ARG230 4.8 96.3 1.0 CA A:SER232 4.8 96.3 1.0 CA A:ARG230 4.8 96.3 1.0 CA A:VAL276 4.9 96.3 1.0

Sodium binding site 2 out of 4 in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ E:Na403 b:84.8 occ:1.00 O E:SER232 2.7 96.3 1.0 O E:ARG230 2.8 96.3 1.0 OD2 E:ASP228 3.0 80.9 1.0 CG E:ASP228 3.8 80.9 1.0 C E:ARG230 3.8 96.3 1.0 C E:SER232 3.9 96.3 1.0 CB E:ASP228 4.2 80.9 1.0 C E:ASN231 4.3 96.3 1.0 N E:SER232 4.3 96.3 1.0 O E:LEU275 4.4 96.3 1.0 ND1 E:HIS233 4.4 96.3 1.0 CA E:ASN231 4.4 96.3 1.0 O E:VAL276 4.5 96.3 1.0 N E:ASN231 4.6 96.3 1.0 NE2 A:HIS69 4.6 107.6 1.0 O E:ASN231 4.7 96.3 1.0 CA E:HIS233 4.7 96.3 1.0 N E:HIS233 4.7 96.3 1.0 OD1 E:ASP228 4.7 80.9 1.0 CE1 E:HIS233 4.7 96.3 1.0 N E:ARG230 4.8 96.3 1.0 CA E:SER232 4.8 96.3 1.0 CA E:ARG230 4.8 96.3 1.0 CA E:VAL276 4.9 96.3 1.0

Sodium binding site 3 out of 4 in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ I:Na404 b:84.8 occ:1.00 O I:SER232 2.7 96.3 1.0 O I:ARG230 2.8 96.3 1.0 OD2 I:ASP228 3.0 80.9 1.0 CG I:ASP228 3.8 80.9 1.0 C I:ARG230 3.8 96.3 1.0 C I:SER232 3.9 96.3 1.0 CB I:ASP228 4.2 80.9 1.0 C I:ASN231 4.3 96.3 1.0 N I:SER232 4.3 96.3 1.0 O I:LEU275 4.4 96.3 1.0 ND1 I:HIS233 4.4 96.3 1.0 CA I:ASN231 4.4 96.3 1.0 O I:VAL276 4.5 96.3 1.0 N I:ASN231 4.6 96.3 1.0 NE2 E:HIS69 4.6 107.6 1.0 O I:ASN231 4.7 96.3 1.0 CA I:HIS233 4.7 96.3 1.0 N I:HIS233 4.7 96.3 1.0 OD1 I:ASP228 4.7 80.9 1.0 CE1 I:HIS233 4.7 96.3 1.0 N I:ARG230 4.8 96.3 1.0 CA I:SER232 4.8 96.3 1.0 CA I:ARG230 4.8 96.3 1.0 CA I:VAL276 4.9 96.3 1.0

Sodium binding site 4 out of 4 in the Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Cryoem Structure of GIRK2-PIP2/Chs - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with Modulators Cholesteryl Hemisuccinate and PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ M:Na404 b:84.8 occ:1.00 O M:SER232 2.7 96.3 1.0 O M:ARG230 2.8 96.3 1.0 OD2 M:ASP228 3.0 80.9 1.0 CG M:ASP228 3.8 80.9 1.0 C M:ARG230 3.8 96.3 1.0 C M:SER232 3.9 96.3 1.0 CB M:ASP228 4.2 80.9 1.0 C M:ASN231 4.3 96.3 1.0 N M:SER232 4.3 96.3 1.0 O M:LEU275 4.4 96.3 1.0 ND1 M:HIS233 4.4 96.3 1.0 CA M:ASN231 4.4 96.3 1.0 O M:VAL276 4.5 96.3 1.0 N M:ASN231 4.6 96.3 1.0 NE2 I:HIS69 4.6 107.6 1.0 O M:ASN231 4.7 96.3 1.0 CA M:HIS233 4.7 96.3 1.0 N M:HIS233 4.7 96.3 1.0 OD1 M:ASP228 4.7 80.9 1.0 CE1 M:HIS233 4.7 96.3 1.0 N M:ARG230 4.8 96.3 1.0 CA M:SER232 4.8 96.3 1.0 CA M:ARG230 4.8 96.3 1.0 CA M:VAL276 4.9 96.3 1.0

Y.K.Mathiharan, I.W.Glaaser, Y.Zhao, M.J.Robertson, G.Skiniotis, P.A.Slesinger. Structural Insights Into GIRK2 Channel Modulation By Cholesterol and PIP2 Cell Rep V. 36 09619 2021.
ISSN: ESSN 2211-1247
DOI: 10.1016/J.CELREP.2021.109619