Sodium in PDB 6xeu: Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2

The structure of Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 also contains other interesting chemical elements:

Potassium

(K)

8 atoms

The binding sites of Sodium atom in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 (pdb code 6xeu). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2, PDB code: 6xeu:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na409 b:102.5 occ:1.00 O A:ARG230 2.9 108.1 1.0 O A:SER232 2.9 111.7 1.0 OD2 A:ASP228 3.4 98.8 1.0 C A:SER232 4.0 111.7 1.0 CB A:ASP228 4.1 98.8 1.0 C A:ARG230 4.1 108.1 1.0 CG A:ASP228 4.1 98.8 1.0 O A:LEU275 4.2 108.1 1.0 C A:ASN231 4.5 109.5 1.0 N A:SER232 4.5 111.7 1.0 NE2 J:HIS69 4.6 122.2 1.0 ND1 A:HIS233 4.7 110.6 1.0 CA A:HIS233 4.7 110.6 1.0 CA A:ASN231 4.7 109.5 1.0 O A:ASN231 4.7 109.5 1.0 O A:VAL276 4.8 108.1 1.0 N A:HIS233 4.8 110.6 1.0 N A:ASN231 4.9 109.5 1.0 N A:ARG230 4.9 108.1 1.0 CA A:VAL276 4.9 108.1 1.0 CA A:SER232 4.9 111.7 1.0

Sodium binding site 2 out of 4 in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Na402 b:102.5 occ:1.00 O D:ARG230 2.9 108.1 1.0 O D:SER232 2.9 111.7 1.0 OD2 D:ASP228 3.4 98.8 1.0 C D:SER232 4.0 111.7 1.0 CB D:ASP228 4.1 98.8 1.0 C D:ARG230 4.1 108.1 1.0 CG D:ASP228 4.1 98.8 1.0 O D:LEU275 4.2 108.1 1.0 C D:ASN231 4.5 109.5 1.0 N D:SER232 4.5 111.7 1.0 NE2 A:HIS69 4.6 122.2 1.0 ND1 D:HIS233 4.7 110.6 1.0 CA D:HIS233 4.7 110.6 1.0 CA D:ASN231 4.7 109.5 1.0 O D:ASN231 4.7 109.5 1.0 O D:VAL276 4.8 108.1 1.0 N D:HIS233 4.8 110.6 1.0 N D:ASN231 4.9 109.5 1.0 N D:ARG230 4.9 108.1 1.0 CA D:VAL276 4.9 108.1 1.0 CA D:SER232 4.9 111.7 1.0

Sodium binding site 3 out of 4 in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ G:Na403 b:102.5 occ:1.00 O G:ARG230 2.9 108.1 1.0 O G:SER232 2.9 111.7 1.0 OD2 G:ASP228 3.4 98.8 1.0 C G:SER232 4.0 111.7 1.0 CB G:ASP228 4.1 98.8 1.0 C G:ARG230 4.1 108.1 1.0 CG G:ASP228 4.1 98.8 1.0 O G:LEU275 4.2 108.1 1.0 C G:ASN231 4.5 109.5 1.0 N G:SER232 4.5 111.7 1.0 NE2 D:HIS69 4.6 122.2 1.0 ND1 G:HIS233 4.7 110.6 1.0 CA G:HIS233 4.7 110.6 1.0 CA G:ASN231 4.7 109.5 1.0 O G:ASN231 4.7 109.5 1.0 O G:VAL276 4.8 108.1 1.0 N G:HIS233 4.8 110.6 1.0 N G:ASN231 4.9 109.5 1.0 N G:ARG230 4.9 108.1 1.0 CA G:VAL276 4.9 108.1 1.0 CA G:SER232 4.9 111.7 1.0

Sodium binding site 4 out of 4 in the Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Cryoem Structure of GIRK2PIP2* - G Protein-Gated Inwardly Rectifying Potassium Channel GIRK2 with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ J:Na402 b:102.5 occ:1.00 O J:ARG230 2.9 108.1 1.0 O J:SER232 2.9 111.7 1.0 OD2 J:ASP228 3.4 98.8 1.0 C J:SER232 4.0 111.7 1.0 CB J:ASP228 4.1 98.8 1.0 C J:ARG230 4.1 108.1 1.0 CG J:ASP228 4.1 98.8 1.0 O J:LEU275 4.2 108.1 1.0 C J:ASN231 4.5 109.5 1.0 N J:SER232 4.5 111.7 1.0 NE2 G:HIS69 4.6 122.2 1.0 ND1 J:HIS233 4.7 110.6 1.0 CA J:HIS233 4.7 110.6 1.0 CA J:ASN231 4.7 109.5 1.0 O J:ASN231 4.7 109.5 1.0 O J:VAL276 4.8 108.1 1.0 N J:HIS233 4.8 110.6 1.0 N J:ASN231 4.9 109.5 1.0 N J:ARG230 4.9 108.1 1.0 CA J:VAL276 4.9 108.1 1.0 CA J:SER232 4.9 111.7 1.0

Y.K.Mathiharan, I.W.Glaaser, Y.Zhao, M.J.Robertson, G.Skiniotis, P.A.Slesinger. Structural Insights Into GIRK2 Channel Modulation By Cholesterol and PIP2 Cell Rep V. 36 09619 2021.
ISSN: ESSN 2211-1247
DOI: 10.1016/J.CELREP.2021.109619