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Atomistry » Sodium » PDB 6vf7-6w0r » 6vnd » |
Sodium in PDB 6vnd: Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636Enzymatic activity of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
All present enzymatic activity of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636:
1.3.5.2; Protein crystallography data
The structure of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636, PDB code: 6vnd
was solved by
A.Padyana,
L.Jin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6vnd:
The structure of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636 also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
(pdb code 6vnd). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636, PDB code: 6vnd: Jump to Sodium binding site number: 1; 2; 3; Sodium binding site 1 out of 3 in 6vndGo back to Sodium Binding Sites List in 6vnd
Sodium binding site 1 out
of 3 in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
Mono view Stereo pair view
Sodium binding site 2 out of 3 in 6vndGo back to Sodium Binding Sites List in 6vnd
Sodium binding site 2 out
of 3 in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
Mono view Stereo pair view
Sodium binding site 3 out of 3 in 6vndGo back to Sodium Binding Sites List in 6vnd
Sodium binding site 3 out
of 3 in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
Mono view Stereo pair view
Reference:
G.Mcdonald,
V.Chubukov,
J.Coco,
K.Truskowski,
R.Narayanaswamy,
S.Choe,
M.Steadman,
E.Artin,
A.K.Padyana,
L.Jin,
S.Ronseaux,
C.Locuson,
Z.P.Fan,
T.Erdmann,
A.Mann,
S.Hayes,
M.Fletcher,
K.Nellore,
S.S.Rao,
H.Subramanya,
S.R.Kunnam,
S.K.Panigrahi,
T.Anthony,
S.Gopinath,
Z.Sui,
N.Nagaraja,
L.Dang,
G.Lenz,
J.Hurov,
S.A.Biller,
J.Murtie,
K.M.Marks,
D.B.Ulanet.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed By Ag-636, A Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol.Cancer Ther. 2020.
Page generated: Tue Oct 8 14:24:42 2024
ISSN: ESSN 1538-8514 PubMed: 33082276 DOI: 10.1158/1535-7163.MCT-20-0550 |
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