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Atomistry » Sodium » PDB 6toy-6u6c » 6ts4 » |
Sodium in PDB 6ts4: Coagulation Factor XI Protease Domain in Complex with Active Site InhibitorEnzymatic activity of Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor
All present enzymatic activity of Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor:
3.4.21.27; Protein crystallography data
The structure of Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor, PDB code: 6ts4
was solved by
M.Renatus,
N.Schiering,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor
(pdb code 6ts4). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor, PDB code: 6ts4: Sodium binding site 1 out of 1 in 6ts4Go back to![]() ![]()
Sodium binding site 1 out
of 1 in the Coagulation Factor XI Protease Domain in Complex with Active Site Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
E.Lorthiois,
J.Roache,
D.Barnes-Seeman,
E.Altmann,
U.Hassiepen,
G.Turner,
R.Duvadie,
V.Hornak,
R.G.Karki,
N.Schiering,
W.A.Weihofen,
F.Perruccio,
A.Calhoun,
T.Fazal,
D.Dedic,
C.Durand,
S.Dussauge,
K.Fettis,
F.Tritsch,
C.Dentel,
A.Druet,
D.Liu,
L.Kirman,
J.Lachal,
K.Namoto,
D.Bevan,
R.Mo,
G.Monnet,
L.Muller,
R.Zessis,
X.Huang,
L.Lindsley,
T.Currie,
Y.H.Chiu,
C.Fridrich,
P.Delgado,
S.Wang,
M.Hollis-Symynkywicz,
J.Berghausen,
E.Williams,
H.Liu,
G.Liang,
H.Kim,
P.Hoffmann,
A.Hein,
P.Ramage,
A.D'arcy,
S.Harlfinger,
M.Renatus,
S.Ruedisser,
D.Feldman,
J.Elliott,
R.Sedrani,
J.Maibaum,
C.M.Adams.
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor Xia Inhibitors: Demonstrating the Power of An Integrated S1 Protease Family Approach. J.Med.Chem. V. 63 8088 2020.
Page generated: Tue Oct 8 14:04:22 2024
ISSN: ISSN 0022-2623 PubMed: 32551603 DOI: 10.1021/ACS.JMEDCHEM.0C00279 |
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