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Sodium in PDB 6qzh: Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana

Enzymatic activity of Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana

All present enzymatic activity of Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana:
3.2.1.18;

Protein crystallography data

The structure of Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana, PDB code: 6qzh was solved by K.Jaeger, S.Bruenle, T.Weinert, W.Guba, J.Muehle, T.Miyazaki, M.Weber, A.Furrer, N.Haenggi, T.Tetaz, C.Y.Huang, D.Mattle, J.M.Vonach, A.Gast, A.Kuglstatter, M.G.Rudolph, P.Nogly, J.Benz, R.J.P.Dawson, J.Standfuss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.20 / 2.10
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.124, 128.809, 100.576, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 24.2

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana (pdb code 6qzh). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana, PDB code: 6qzh:

Sodium binding site 1 out of 1 in 6qzh

Go back to Sodium Binding Sites List in 6qzh
Sodium binding site 1 out of 1 in the Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of the Human Cc Chemokine Receptor 7 in Complex with the Intracellular Allosteric Antagonist CMP2105 and the Insertion Protein Sialidase Nana within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1503

b:80.3
occ:1.00
 OD1 A:ASN76 2.4 80.4 1.0
O A:HOH1686 2.4 75.0 1.0
OD2 A:ASP104 3.0 89.7 1.0
OD1 A:ASN322 3.1 79.7 1.0
CB A:ASN322 3.5 87.8 1.0
CG A:ASN76 3.5 84.5 1.0
CG A:ASN322 3.7 79.7 1.0
CG A:ASP104 3.8 85.6 1.0
CA A:ALA101 3.9 74.7 1.0
ND2 A:ASN76 4.0 86.8 1.0
CB A:ASP104 4.0 79.1 1.0
CB A:ALA101 4.0 78.9 1.0
CD A:PRO323 4.2 99.3 1.0
CD2 A:LEU100 4.2 71.7 1.0
CE2 A:TYR326 4.3 87.5 1.0
O A:LEU100 4.3 76.2 1.0
N A:ALA101 4.3 69.2 1.0
CG A:PRO323 4.4 96.1 1.0
OH A:TYR326 4.5 92.2 1.0
C A:ASN322 4.5 93.0 1.0
N A:PRO323 4.5 0.1 1.0
C A:LEU100 4.6 71.6 1.0
CA A:ASN322 4.6 89.2 1.0
CZ A:TYR326 4.7 88.6 1.0
CB A:ASN76 4.8 85.4 1.0
OD1 A:ASP104 4.8 85.3 1.0
O A:ASN322 4.9 89.6 1.0

Reference:

K.Jaeger, S.Bruenle, T.Weinert, W.Guba, J.Muehle, T.Miyazaki, M.Weber, A.Furrer, N.Haenggi, T.Tetaz, C.Y.Huang, D.Mattle, J.M.Vonach, A.Gast, A.Kuglstatter, M.G.Rudolph, P.Nogly, J.Benz, R.J.P.Dawson, J.Standfuss. Structural Basis For Allosteric Ligand Recognition in the Human Cc Chemokine Receptor 7. Cell V. 178 1222 2019.
ISSN: ISSN 1097-4172
PubMed: 31442409
DOI: 10.1016/J.CELL.2019.07.028
Page generated: Tue Dec 15 12:51:27 2020

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