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Sodium in PDB 6o3a: Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab

Protein crystallography data

The structure of Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab, PDB code: 6o3a was solved by S.Raman, M.Beilschmidt, J.Fransson, J.P.Julien, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.55 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 41.544, 103.446, 144.207, 90.00, 90.00, 90.00
R / Rfree (%) 19.2 / 24.2

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab (pdb code 6o3a). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab, PDB code: 6o3a:

Sodium binding site 1 out of 1 in 6o3a

Go back to Sodium Binding Sites List in 6o3a
Sodium binding site 1 out of 1 in the Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Frizzled 7 Crd in Complex with F7.B Fab within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na306

b:23.5
occ:1.00
OG A:SER77 2.9 36.8 1.0
NE2 A:GLN79 3.6 34.1 1.0
CB A:SER77 3.7 31.4 1.0
CD A:GLN79 4.7 30.9 1.0
OE1 A:GLN79 5.0 29.0 1.0

Reference:

S.Raman, M.Beilschmidt, M.To, K.Lin, F.Lui, Y.Jmeian, M.Ng, M.Fernandez, Y.Fu, K.Mascall, A.Duque, X.Wang, G.Pan, S.Angers, J.Moffat, S.S.Sidhu, J.Magram, A.M.Sinclair, J.Fransson, J.P.Julien. Structure-Guided Design Fine-Tunes Pharmacokinetics, Tolerability, and Antitumor Profile of Multispecific Frizzled Antibodies. Proc. Natl. Acad. Sci. V. 116 6812 2019U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30894493
DOI: 10.1073/PNAS.1817246116
Page generated: Tue Dec 15 12:40:51 2020

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