Sodium in PDB 6mp3: Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine

All present enzymatic activity of Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine:
2.7.7.7;

The structure of Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine, PDB code: 6mp3 was solved by M.A.Hawkins, H.Jung, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.72 / 1.91
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	98.650, 98.650, 81.242, 90.00, 90.00, 120.00
R / Rfree (%)	16.8 / 20.9

The binding sites of Sodium atom in the Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine (pdb code 6mp3). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine, PDB code: 6mp3:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine within 5.0Å range: probe atom residue distance (Å) B Occ A:Na501 b:55.0 occ:1.00 O A:HOH842 1.6 44.5 1.0 O A:HOH844 2.4 52.7 1.0 O A:HOH843 2.9 42.0 1.0 O A:HOH601 2.9 36.9 1.0 O A:ASP176 3.0 41.4 1.0 O A:HOH833 3.2 46.6 1.0 O A:LEU178 3.4 32.0 1.0 O A:SER177 3.9 39.2 1.0 C A:SER177 4.0 34.9 1.0 C A:ASP176 4.2 34.7 1.0 HA A:SER177 4.2 38.8 1.0 N A:LEU178 4.2 31.0 1.0 C A:LEU178 4.3 50.7 1.0 H A:LEU178 4.4 37.1 1.0 CA A:SER177 4.6 32.4 1.0 HA A:GLN179 4.7 71.6 1.0 N A:SER177 4.9 31.5 1.0 CA A:LEU178 4.9 31.7 1.0 O A:LEU175 5.0 30.2 1.0 HA A:ASP176 5.0 34.4 1.0 H A:ILE180 5.0 98.9 1.0

Sodium binding site 2 out of 2 in the Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Binary Structure of Dna Polymerase Eta in Complex with Templating Hypoxanthine within 5.0Å range: probe atom residue distance (Å) B Occ A:Na502 b:43.8 occ:1.00 O A:HOH608 2.1 39.3 1.0 HG A:SER185 2.1 40.6 1.0 O A:HOH725 2.4 35.1 1.0 OG A:SER185 2.7 33.9 1.0 OE1 A:GLN179 3.0 61.9 1.0 OD2 A:ASP187 3.1 35.7 1.0 HB2 A:GLN179 3.3 75.9 1.0 HB2 A:ASP187 3.3 24.7 1.0 CD A:GLN179 3.7 63.4 1.0 H A:ASP187 3.7 23.0 1.0 HB2 A:SER185 3.7 55.9 1.0 CB A:SER185 3.8 46.6 1.0 CG A:ASP187 3.9 29.3 1.0 HD2 A:PRO186 4.0 33.7 1.0 CB A:GLN179 4.0 63.3 1.0 CB A:ASP187 4.1 20.6 1.0 HB3 A:GLN179 4.2 75.9 1.0 CG A:GLN179 4.3 77.5 1.0 HA A:SER185 4.4 41.5 1.0 NE2 A:GLN179 4.4 51.3 1.0 O A:HOH607 4.5 48.0 1.0 HG2 A:GLN179 4.5 92.9 1.0 HB3 A:SER185 4.5 55.9 1.0 HE21 A:GLN179 4.5 61.5 1.0 N A:ASP187 4.5 19.2 1.0 CA A:SER185 4.6 34.6 1.0 O A:HOH759 4.7 46.5 1.0 HB3 A:ASP187 4.8 24.7 1.0 H A:LEU188 4.8 23.3 1.0 CD A:PRO186 4.9 28.1 1.0 OD1 A:ASP187 4.9 21.9 1.0 CA A:ASP187 4.9 20.6 1.0 N A:PRO186 5.0 24.0 1.0 C A:SER185 5.0 27.4 1.0 HE22 A:GLN179 5.0 61.5 1.0

M.A.Hawkins, J.Hunmin, S.Lee. Structural Analysis of Translesion Synthesis Across Hypoxanthine Lesion Using Human Dna Polymerase Eta To Be Published.