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Sodium in PDB 6h19: Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form)

Enzymatic activity of Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form)

All present enzymatic activity of Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form):
3.1.1.13; 3.1.1.3;

Protein crystallography data

The structure of Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form), PDB code: 6h19 was solved by C.Touvrey, X.Brazzolotto, F.Nachon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.70 / 1.89
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.120, 97.810, 110.150, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 23

Other elements in 6h19:

The structure of Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form) also contains other interesting chemical elements:

Zinc (Zn) 10 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form) (pdb code 6h19). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form), PDB code: 6h19:

Sodium binding site 1 out of 1 in 6h19

Go back to Sodium Binding Sites List in 6h19
Sodium binding site 1 out of 1 in the Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Ethyl-Paraoxon Inhibited Recombinant Human Bile Salt Activated Lipase (Aged Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na618

b:42.9
occ:1.00
 OD1 A:ASP126 2.8 38.7 1.0
O A:HOH887 2.9 38.0 1.0
O A:HOH728 2.9 41.0 1.0
CG A:ASP126 3.4 30.5 1.0
OE1 A:GLU128 3.4 39.3 1.0
OD2 A:ASP126 3.5 29.4 1.0
NZ A:LYS18 3.6 38.2 1.0
ND2 A:ASN122 4.1 32.4 1.0
CD A:GLU128 4.2 38.3 1.0
O A:HOH875 4.4 33.9 1.0
CB A:ASP126 4.5 30.2 1.0
CB A:GLU128 4.5 29.9 1.0
OE2 A:GLU128 4.7 44.1 1.0
O A:HOH784 4.8 38.0 1.0

Reference:

C.Touvrey, C.Courageux, V.Guillon, R.Terreux, F.Nachon, X.Brazzolotto. X-Ray Structures of Human Bile-Salt Activated Lipase Conjugated to Nerve Agents Surrogates. Toxicology V. 411 15 2019.
ISSN: ISSN 1879-3185
PubMed: 30359675
DOI: 10.1016/J.TOX.2018.10.015
Page generated: Tue Dec 15 12:18:51 2020

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