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Sodium in PDB 6c7x: Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine

Enzymatic activity of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine

All present enzymatic activity of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine, PDB code: 6c7x was solved by T.S.Peat, P.Mujumdar, S.A.Poulsen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.40 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.311, 41.425, 72.424, 90.00, 104.51, 90.00
R / Rfree (%) 15.4 / 18.8

Other elements in 6c7x:

The structure of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine (pdb code 6c7x). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine, PDB code: 6c7x:

Sodium binding site 1 out of 1 in 6c7x

Go back to Sodium Binding Sites List in 6c7x
Sodium binding site 1 out of 1 in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na303

b:35.4
occ:1.00
 O A:HOH402 2.2 28.7 1.0
OE2 A:GLU214 2.7 26.7 1.0
O A:PRO215 2.9 11.1 1.0
O A:HOH605 3.0 19.9 1.0
O A:HOH601 3.2 27.6 1.0
CD A:GLU214 3.7 15.3 1.0
CB A:PRO186 3.7 10.2 1.0
O A:HOH411 3.8 34.2 1.0
CA A:ILE216 3.8 10.4 1.0
CA A:PRO186 3.9 10.3 1.0
C A:PRO215 3.9 9.9 1.0
CG A:GLU214 4.0 12.7 1.0
CG2 A:ILE216 4.2 10.4 1.0
N A:ILE216 4.3 9.7 1.0
N A:GLU187 4.4 11.8 1.0
CB A:ILE216 4.5 10.0 1.0
N A:SER217 4.6 10.8 1.0
OE1 A:GLU214 4.7 14.5 1.0
C A:ILE216 4.7 10.4 1.0
C A:PRO186 4.7 11.5 1.0
NZ A:LYS154 4.8 20.1 1.0
N A:PRO186 5.0 9.9 1.0

Reference:

P.Mujumdar, S.Bua, C.T.Supuran, T.S.Peat, S.A.Poulsen. Synthesis, Structure and Bioactivity of Primary Sulfamate-Containing Natural Products. Bioorg. Med. Chem. Lett. V. 28 3009 2018.
ISSN: ESSN 1464-3405
PubMed: 29685656
DOI: 10.1016/J.BMCL.2018.04.038
Page generated: Tue Oct 8 06:31:45 2024

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