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Sodium in PDB 6c4k: Full Length Hugdh with A104L Substitution in the Absence of Ligand

Enzymatic activity of Full Length Hugdh with A104L Substitution in the Absence of Ligand

All present enzymatic activity of Full Length Hugdh with A104L Substitution in the Absence of Ligand:
1.1.1.22;

Protein crystallography data

The structure of Full Length Hugdh with A104L Substitution in the Absence of Ligand, PDB code: 6c4k was solved by N.R.Beattie, B.J.Pioso, Z.A.Wood, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.16 / 2.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 178.520, 114.470, 96.880, 90.00, 116.50, 90.00
R / Rfree (%) 22.2 / 25.5

Sodium Binding Sites:

The binding sites of Sodium atom in the Full Length Hugdh with A104L Substitution in the Absence of Ligand (pdb code 6c4k). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Full Length Hugdh with A104L Substitution in the Absence of Ligand, PDB code: 6c4k:

Sodium binding site 1 out of 1 in 6c4k

Go back to Sodium Binding Sites List in 6c4k
Sodium binding site 1 out of 1 in the Full Length Hugdh with A104L Substitution in the Absence of Ligand


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Full Length Hugdh with A104L Substitution in the Absence of Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na501

b:82.5
occ:1.00
SD B:MET98 3.5 0.6 1.0
CG C:ARG312 3.6 71.4 1.0
CD1 C:TYR356 3.8 72.5 1.0
CG B:MET98 3.9 0.1 1.0
CG C:TYR356 4.0 66.6 1.0
OG C:SER316 4.0 73.9 1.0
CE1 C:TYR356 4.1 82.6 1.0
CD C:ARG312 4.3 0.4 1.0
CD2 C:TYR356 4.4 77.1 1.0
CB C:TYR356 4.4 67.1 1.0
O C:ARG312 4.4 60.4 1.0
CZ C:TYR356 4.5 87.0 1.0
CE2 C:TYR356 4.6 83.2 1.0
CB C:ARG312 4.7 70.8 1.0
CA C:ARG312 4.8 67.6 1.0
CB C:ALA315 4.8 66.2 1.0

Reference:

N.R.Beattie, B.J.Pioso, A.M.Sidlo, N.D.Keul, Z.A.Wood. Hysteresis and Allostery in Human Udp-Glucose Dehydrogenase Require A Flexible Protein Core. Biochemistry V. 57 6848 2018.
ISSN: ISSN 1520-4995
PubMed: 30457329
DOI: 10.1021/ACS.BIOCHEM.8B00497
Page generated: Tue Oct 8 06:30:30 2024

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