Sodium in PDB 6bwi: 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4

The binding sites of Sodium atom in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 (pdb code 6bwi). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 5 binding sites of Sodium where determined in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4, PDB code: 6bwi:
Jump to Sodium binding site number: 1; 2; 3; 4; 5;

Sodium binding site 1 out of 5 in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1201 b:94.2 occ:1.00 CA D:GLY976 3.3 48.8 1.0 CA A:GLY976 3.4 50.1 1.0 CA C:GLY976 3.7 48.0 1.0 N C:GLY976 3.8 48.0 1.0 N A:GLY976 3.9 50.1 1.0 N D:GLY976 4.0 48.8 1.0 O D:GLY976 4.1 48.8 1.0 C D:GLY976 4.2 48.8 1.0 CA B:GLY976 4.2 49.3 1.0 N B:GLY976 4.4 49.3 1.0 O B:GLY976 4.6 49.3 1.0 C A:GLY976 4.6 50.1 1.0 C C:GLY976 4.7 48.0 1.0 O C:GLY976 4.7 48.0 1.0 C A:PHE975 4.9 45.8 1.0 C B:GLY976 4.9 49.3 1.0 O A:GLY976 4.9 50.1 1.0 NA B:NA1201 5.0 94.2 1.0 C C:PHE975 5.0 44.5 1.0

Sodium binding site 2 out of 5 in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1202 b:30.0 occ:1.00 OG B:SER1044 3.1 38.2 1.0 OG C:SER1044 3.1 38.1 1.0 OG D:SER1044 3.1 38.2 1.0 OG A:SER1044 3.1 37.9 1.0 CB B:SER1044 3.6 38.2 1.0 CB C:SER1044 3.6 38.1 1.0 CB D:SER1044 3.6 38.2 1.0 CB A:SER1044 3.6 37.9 1.0 NA A:NA1203 4.4 94.2 1.0 O C:ILE1040 4.5 33.9 1.0 O D:ILE1040 4.6 34.6 1.0 O B:ILE1040 4.6 34.2 1.0 O A:ILE1040 4.6 34.0 1.0 CG2 C:ILE1040 4.6 33.9 1.0 CG2 D:ILE1040 4.7 34.6 1.0 CG2 B:ILE1040 4.7 34.2 1.0 CG2 A:ILE1040 4.7 34.0 1.0

Sodium binding site 3 out of 5 in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1203 b:94.2 occ:1.00 OG C:SER1044 3.6 38.1 1.0 OG B:SER1044 3.6 38.2 1.0 OG D:SER1044 3.6 38.2 1.0 OG A:SER1044 3.6 37.9 1.0 NA A:NA1202 4.4 30.0 1.0 O C:SER1044 4.5 38.1 1.0 O B:SER1044 4.5 38.2 1.0 O D:SER1044 4.5 38.2 1.0 O A:SER1044 4.5 37.9 1.0 CB C:SER1044 4.9 38.1 1.0 CB B:SER1044 4.9 38.2 1.0 CB D:SER1044 4.9 38.2 1.0 CB A:SER1044 5.0 37.9 1.0

Sodium binding site 4 out of 5 in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1201 b:94.2 occ:1.00 O D:GLY976 3.3 48.8 1.0 O C:GLY976 3.3 48.0 1.0 O B:GLY976 3.4 49.3 1.0 O A:GLY976 3.4 50.1 1.0 OE1 B:GLN977 3.5 20.0 1.0 OE1 D:GLN977 4.0 20.0 1.0 OE1 A:GLN977 4.1 20.0 1.0 C A:GLY976 4.2 50.1 1.0 C D:GLY976 4.4 48.8 1.0 C C:GLY976 4.4 48.0 1.0 OE1 C:GLN977 4.5 20.0 1.0 C B:GLY976 4.6 49.3 1.0 CD B:GLN977 4.6 20.0 1.0 CA A:GLY976 4.6 50.1 1.0 CD D:GLN977 4.8 20.0 1.0 CA C:GLY976 5.0 48.0 1.0 NA A:NA1201 5.0 94.2 1.0

Sodium binding site 5 out of 5 in the 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of 3.7 Angstrom Cryoem Structure of Full Length Human TRPM4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1202 b:94.2 occ:1.00 O B:SER1143 4.8 57.5 1.0 O C:SER1143 4.9 54.5 1.0 OG A:SER1143 4.9 56.2 1.0 OG D:SER1143 4.9 56.9 1.0 OG B:SER1143 5.0 57.5 1.0

J.Duan, Z.Li, J.Li, A.Santa-Cruz, S.Sanchez-Martinez, J.Zhang, D.E.Clapham. Structure of Full-Length Human TRPM4. Proc.Natl.Acad.Sci.Usa V. 115 2377 2018.
ISSN: ESSN 1091-6490
PubMed: 29463718
DOI: 10.1073/PNAS.1722038115