Sodium in PDB 5x5g: Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595

All present enzymatic activity of Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595:
3.5.2.6;

The structure of Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595, PDB code: 5x5g was solved by J.Wachino, W.Jin, Y.Arakawa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.22 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	95.190, 67.910, 45.320, 90.00, 94.60, 90.00
R / Rfree (%)	16.1 / 20.9

The binding sites of Sodium atom in the Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595 (pdb code 5x5g). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595, PDB code: 5x5g:

Sodium binding site 1 out of 1 in the Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Tla-3 Extended-Spectrum Beta-Lactamase in A Complex with OP0595 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na304 b:23.1 occ:1.00 O A:ALA162 2.8 18.2 1.0 O A:MET159 2.8 16.7 1.0 O A:HOH480 2.9 17.3 1.0 O A:TRP163 2.9 19.2 1.0 N A:GLN166 3.0 14.9 1.0 CB A:GLN166 3.4 15.5 1.0 C A:TRP163 3.4 19.1 1.0 N A:VAL165 3.6 15.9 1.0 O A:HOH467 3.6 28.4 1.0 CG A:GLN166 3.6 15.8 1.0 CA A:GLN166 3.7 14.9 1.0 C A:MET159 3.7 19.9 1.0 C A:ALA162 3.7 19.4 1.0 CA A:TRP163 3.8 18.7 1.0 NE2 A:GLN166 3.8 17.8 1.0 CA A:MET159 3.9 16.9 1.0 C A:VAL165 3.9 15.1 1.0 CD A:GLN166 4.0 17.1 1.0 CB A:MET159 4.0 16.9 1.0 CA A:VAL165 4.0 16.7 1.0 CB A:VAL165 4.0 18.8 1.0 N A:TRP163 4.2 17.1 1.0 N A:ASN164 4.3 18.8 1.0 CG A:MET159 4.4 16.8 1.0 C A:ASN164 4.4 18.3 1.0 NE2 A:GLN55 4.8 16.8 1.0 O A:HOH496 4.8 21.4 1.0 OE1 A:GLN166 4.9 17.8 1.0 CA A:ASN164 4.9 17.3 1.0 N21 A:OP0305 4.9 37.0 1.0 CG1 A:VAL165 4.9 19.9 1.0 N A:HIS160 5.0 18.4 1.0 SD A:MET159 5.0 17.9 1.0

W.Jin, J.Wachino, Y.Yamaguchi, K.Kimura, A.Kumar, M.Yamada, A.Morinaka, Y.Sakamaki, M.Yonezawa, H.Kurosaki, Y.Arakawa. Structural Insights Into the Tla-3 Extended-Spectrum Beta-Lactamase and Its Inhibition By Avibactam and OP0595. Antimicrob. Agents V. 61 2017CHEMOTHER..
ISSN: ESSN 1098-6596
PubMed: 28739781
DOI: 10.1128/AAC.00501-17