Atomistry » Sodium » PDB 5vb8-5vwn » 5vs2
Atomistry »
  Sodium »
    PDB 5vb8-5vwn »
      5vs2 »

Sodium in PDB 5vs2: Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation

Enzymatic activity of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation

All present enzymatic activity of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation:
2.7.7.7;

Protein crystallography data

The structure of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation, PDB code: 5vs2 was solved by A.J.Reed, Z.Suo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.64 / 2.33
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.940, 80.490, 55.660, 90.00, 107.28, 90.00
R / Rfree (%) 18.7 / 25

Other elements in 5vs2:

The structure of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation also contains other interesting chemical elements:

Calcium (Ca) 3 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation (pdb code 5vs2). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation, PDB code: 5vs2:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 5vs2

Go back to Sodium Binding Sites List in 5vs2
Sodium binding site 1 out of 2 in the Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Na101

b:32.9
occ:1.00
O A:VAL65 2.5 27.1 1.0
O A:LYS60 2.5 32.1 1.0
O A:LEU62 2.6 30.0 1.0
OP1 D:DC3 2.6 30.7 1.0
OP2 D:DC3 3.5 26.4 1.0
P D:DC3 3.5 34.5 1.0
C A:LEU62 3.6 28.3 1.0
C A:LYS60 3.6 33.8 1.0
C A:VAL65 3.6 28.2 1.0
N A:VAL65 4.0 25.8 1.0
C A:LYS61 4.1 31.2 1.0
N A:LEU62 4.2 29.6 1.0
CA A:PRO63 4.2 29.1 1.0
O A:LYS61 4.3 29.1 1.0
N A:GLY64 4.3 27.2 1.0
N A:PRO63 4.3 28.4 1.0
CA A:VAL65 4.3 26.5 1.0
CA A:LYS60 4.5 32.1 1.0
CA A:LEU62 4.5 28.5 1.0
N A:LYS61 4.5 30.8 1.0
CB A:VAL65 4.6 28.9 1.0
CA A:LYS61 4.6 32.2 1.0
O3' D:DT2 4.6 29.0 1.0
C A:PRO63 4.7 27.6 1.0
N A:GLY66 4.7 30.4 1.0
O5' D:DC3 4.7 32.2 1.0
CG A:LYS60 4.9 39.0 1.0
CA A:GLY66 4.9 29.8 1.0
C A:GLY64 4.9 25.5 1.0

Sodium binding site 2 out of 2 in 5vs2

Go back to Sodium Binding Sites List in 5vs2
Sodium binding site 2 out of 2 in the Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human Dna Polymerase Beta Pre-Catalytic 8-Oxog:Da Extension Complex with Dttp Bound in Watson-Crick Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na403

b:14.1
occ:1.00
O A:HOH565 2.1 22.1 1.0
OE2 A:GLU249 2.3 28.3 1.0
O A:HOH584 2.4 23.1 1.0
OE1 A:GLU249 2.5 27.8 1.0
CD A:GLU249 2.8 28.6 1.0
O A:HOH502 4.1 24.4 1.0
CG A:GLU249 4.3 26.4 1.0
OE1 A:GLN240 4.6 19.1 1.0
O A:HOH549 4.8 17.9 1.0
NE2 A:GLN240 4.9 18.8 1.0

Reference:

A.J.Reed, Z.Suo. Time-Dependent Extension From An 8-Oxoguanine Lesion By Human Dna Polymerase Beta. J. Am. Chem. Soc. V. 139 9684 2017.
ISSN: ESSN 1520-5126
PubMed: 28682600
DOI: 10.1021/JACS.7B05048
Page generated: Tue Dec 15 11:46:01 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy