Sodium in PDB 5uqa: Insulin with Proline Analog Fzp at Position B28 in the R6 State

The structure of Insulin with Proline Analog Fzp at Position B28 in the R6 State, PDB code: 5uqa was solved by S.A.Lieblich, K.Y.Fang, D.A.Tirrell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.53 / 1.31
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.936, 61.258, 60.390, 90.00, 111.69, 90.00
R / Rfree (%)	15.2 / 18.2

The structure of Insulin with Proline Analog Fzp at Position B28 in the R6 State also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Zinc	(Zn)	2 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Sodium atom in the Insulin with Proline Analog Fzp at Position B28 in the R6 State (pdb code 5uqa). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the Insulin with Proline Analog Fzp at Position B28 in the R6 State, PDB code: 5uqa:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6;

Sodium binding site 1 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ E:Na102 b:30.6 occ:0.92 O E:ASN18 2.3 15.6 1.0 O E:HOH203 2.5 31.1 1.0 O E:CYS20 2.6 25.5 1.0 C E:ASN18 3.2 15.5 1.0 C E:CYS20 3.8 21.8 1.0 O E:GLU17 3.9 17.4 1.0 N E:CYS20 3.9 18.1 1.0 CA E:ASN18 4.0 14.7 1.0 N E:TYR19 4.1 15.4 1.0 C E:TYR19 4.2 15.5 1.0 O E:HOH214 4.2 37.7 1.0 CA E:TYR19 4.4 15.7 1.0 CA E:CYS20 4.4 17.7 1.0 NH2 F:ARG22 4.4 32.7 1.0 OD1 E:ASN18 4.6 14.4 1.0 C E:GLU17 4.8 16.9 1.0 N E:ASN21 4.9 23.8 1.0 CB E:CYS20 4.9 18.2 1.0 O E:TYR19 4.9 18.5 1.0 CG E:ASN18 4.9 13.7 1.0 N E:ASN18 4.9 13.9 1.0

Sodium binding site 2 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ F:Na101 b:31.1 occ:1.00 O F:HOH212 2.3 29.2 1.0 O F:HOH205 2.8 23.8 1.0 ND1 F:HIS10 2.9 14.4 1.0 O J:HOH206 3.1 24.6 1.0 OG J:SER9 3.4 17.4 1.0 CE1 F:HIS10 3.8 14.4 1.0 CG F:HIS10 3.8 12.3 1.0 C3 J:GOL102 3.9 43.4 1.0 O F:HOH218 4.0 26.6 1.0 CG F:GLU13 4.0 22.1 1.0 CB F:HIS10 4.0 11.9 1.0 CB F:GLU13 4.0 14.4 1.0 CA F:HIS10 4.0 11.9 1.0 CG L:GLU13 4.2 19.1 1.0 O F:HOH206 4.2 30.1 1.0 O3 J:GOL102 4.2 43.2 1.0 O F:HIS10 4.3 13.2 1.0 CB J:SER9 4.4 14.4 1.0 O J:HOH212 4.4 23.7 1.0 NA J:NA101 4.5 33.3 1.0 C F:HIS10 4.7 12.4 1.0 NE2 F:HIS10 4.9 11.9 1.0 CD2 F:HIS10 4.9 11.8 1.0

Sodium binding site 3 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ F:Na102 b:33.3 occ:0.63 O B:HOH405 2.3 24.4 1.0 ND2 F:ASN3 3.1 28.4 1.0 OD1 F:ASN3 3.8 30.5 1.0 O F:HOH202 3.8 28.9 1.0 CG F:ASN3 3.8 24.9 1.0 ND2 B:ASN3 4.8 15.3 1.0 CD2 J:PHE1 4.9 20.5 1.0

Sodium binding site 4 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ I:Na102 b:27.9 occ:0.63 O I:HOH204 2.4 40.2 1.0 O J:HOH204 3.0 48.5 1.0 ND2 J:ASN3 4.2 21.9 1.0 O I:HOH219 4.5 35.3 1.0 O I:CYS7 4.5 16.0 1.0 OG1 I:THR8 4.8 22.6 1.0 CG J:ASN3 5.0 20.1 1.0

Sodium binding site 5 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ J:Na101 b:33.3 occ:1.00 OG J:SER9 2.8 17.4 1.0 C3 J:GOL102 3.1 43.4 1.0 CD J:GLU13 3.4 24.4 0.4 OE1 J:GLU13 3.5 26.2 0.4 CE1 F:HIS10 3.5 14.4 1.0 ND1 J:HIS10 3.5 14.1 1.0 C J:SER9 3.6 12.2 1.0 O J:SER9 3.6 13.4 1.0 CE1 J:HIS10 3.6 14.0 1.0 O2 J:GOL102 3.7 44.1 1.0 N J:HIS10 3.7 11.7 1.0 CG J:HIS10 3.7 11.1 1.0 OE2 J:GLU13 3.7 27.0 0.4 C2 J:GOL102 3.8 44.0 1.0 CB J:SER9 3.8 14.4 1.0 CA J:HIS10 3.8 11.3 1.0 CG J:GLU13 3.8 22.1 0.4 NE2 J:HIS10 3.8 12.7 1.0 CD2 J:HIS10 3.9 12.9 1.0 O3 J:GOL102 3.9 43.2 1.0 O J:HOH217 4.3 25.1 1.0 ND1 F:HIS10 4.3 14.4 1.0 O J:HOH205 4.3 22.7 1.0 CA J:SER9 4.3 12.7 1.0 CB J:HIS10 4.4 11.6 1.0 O J:HOH206 4.5 24.6 1.0 NA F:NA101 4.5 31.1 1.0 NE2 F:HIS10 4.5 11.9 1.0 CB J:GLU13 4.7 12.9 0.6 CB J:GLU13 4.7 18.1 0.4 O F:HOH206 5.0 30.1 1.0

Sodium binding site 6 out of 6 in the Insulin with Proline Analog Fzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of Insulin with Proline Analog Fzp at Position B28 in the R6 State within 5.0Å range: probe atom residue distance (Å) B Occ K:Na102 b:44.9 occ:1.00 OG K:SER9 2.7 23.7 0.7 O K:THR8 3.4 20.2 0.9 CB K:SER9 3.7 20.5 0.7 CA K:SER9 3.8 17.2 0.7 CA K:SER9 3.8 17.9 0.3 CB K:SER9 3.9 19.4 0.3 O K:HOH202 3.9 31.4 1.0 C K:THR8 4.0 18.3 0.9 O H:HOH216 4.1 23.3 1.0 N K:SER9 4.1 17.4 0.7 N K:SER9 4.1 17.9 0.3 OG K:SER9 4.4 21.5 0.3 N H:PHE1 4.8 18.2 1.0 CA H:PHE1 4.8 16.2 1.0 CD1 H:PHE1 4.9 17.5 1.0

S.A.Lieblich, K.Y.Fang, D.A.Tirrell. Insulin with Proline Analog Fzp at Position B28 in the R6 State To Be Published.