Atomistry » Sodium » PDB 5syl-5tcd » 5t4h
Atomistry »
  Sodium »
    PDB 5syl-5tcd »
      5t4h »

Sodium in PDB 5t4h: Human DPP4 in Complex with Ligand 34N

Enzymatic activity of Human DPP4 in Complex with Ligand 34N

All present enzymatic activity of Human DPP4 in Complex with Ligand 34N:
3.4.14.5;

Protein crystallography data

The structure of Human DPP4 in Complex with Ligand 34N, PDB code: 5t4h was solved by G.Scapin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 92.91 / 2.61
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 118.125, 126.008, 137.546, 90.00, 90.00, 90.00
R / Rfree (%) 14.8 / 22.6

Sodium Binding Sites:

The binding sites of Sodium atom in the Human DPP4 in Complex with Ligand 34N (pdb code 5t4h). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human DPP4 in Complex with Ligand 34N, PDB code: 5t4h:

Sodium binding site 1 out of 1 in 5t4h

Go back to Sodium Binding Sites List in 5t4h
Sodium binding site 1 out of 1 in the Human DPP4 in Complex with Ligand 34N


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human DPP4 in Complex with Ligand 34N within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na811

b:35.0
occ:1.00
O A:LEU491 2.2 20.9 1.0
O A:GLY490 2.3 21.3 1.0
C A:LEU491 2.9 20.5 1.0
C A:GLY490 3.4 20.9 1.0
N A:ARG492 3.6 16.9 1.0
CA A:LEU491 3.7 15.7 1.0
CA A:ARG492 3.9 15.4 1.0
N A:LEU491 4.0 16.1 1.0
CA A:GLY490 4.6 18.2 1.0
CB A:ARG492 4.8 16.5 1.0
C A:ARG492 5.0 18.1 1.0

Reference:

D.A.Pissarnitski, Z.Zhao, D.Cole, W.L.Wu, M.Domalski, J.W.Clader, G.Scapin, J.Voigt, A.Soriano, T.Kelly, M.A.Powles, Z.Yao, D.A.Burnett. Scaffold-Hopping From Xanthines to Tricyclic Guanines: A Case Study of Dipeptidyl Peptidase 4 (DPP4) Inhibitors. Bioorg.Med.Chem. V. 24 5534 2016.
ISSN: ESSN 1464-3391
PubMed: 27670099
DOI: 10.1016/J.BMC.2016.09.007
Page generated: Tue Dec 15 11:35:35 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy