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Sodium in PDB 5scz: Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224, PDB code: 5scz was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.24 / 1.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 29.5, 67.22, 72.33, 90, 90, 90
R / Rfree (%) 14.6 / 19.5

Other elements in 5scz:

The structure of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224 (pdb code 5scz). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224, PDB code: 5scz:

Sodium binding site 1 out of 1 in 5scz

Go back to Sodium Binding Sites List in 5scz
Sodium binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na203

b:20.0
occ:1.00
 OG1 A:THR113 2.9 9.7 1.0
N06 A:HI9202 3.1 8.7 1.0
O A:GLU111 3.2 11.0 1.0
N A:THR113 3.2 7.3 1.0
O A:TRP6 3.3 7.5 1.0
CD2 A:HIS30 3.4 14.5 1.0
C A:VAL112 3.4 9.6 1.0
CG1 A:ILE5 3.5 7.0 1.0
C A:GLU111 3.6 11.0 1.0
CA A:VAL112 3.7 10.0 1.0
NE2 A:HIS30 3.7 17.6 1.0
N A:VAL112 3.8 9.1 1.0
CB A:THR113 3.8 10.5 1.0
CD1 A:ILE5 3.9 11.2 1.0
CA A:THR113 4.0 9.3 1.0
O A:VAL112 4.0 10.6 1.0
O A:HOH381 4.1 13.5 1.0
OD1 A:ASP27 4.1 10.5 1.0
C A:TRP6 4.1 9.2 1.0
N A:TRP6 4.3 8.3 1.0
C05 A:HI9202 4.3 7.7 1.0
CB A:GLU111 4.5 8.6 1.0
CA A:GLU111 4.6 9.9 1.0
CG A:HIS30 4.6 13.2 1.0
N07 A:HI9202 4.7 7.1 1.0
CA A:TRP6 4.8 9.1 1.0
CB A:ILE5 4.8 6.4 1.0
N A:ALA7 4.9 9.1 1.0
C A:ILE5 5.0 9.2 1.0

Reference:

S.J.Mayclin, J.W.Fairman, D.M.Dranow, D.G.Conrady, D.Fox Iii, C.M.Lukacs, D.D.Lorimer, P.S.Horanyi, T.E.Edwards, J.Abendroth. Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1224 To Be Published.
Page generated: Mon Oct 7 23:54:08 2024

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