Sodium in PDB 5ias: Caspase 3 V266Y

All present enzymatic activity of Caspase 3 V266Y:
3.4.22.56;

The structure of Caspase 3 V266Y, PDB code: 5ias was solved by J.J.Maciag, S.H.Mackenzie, M.B.Tucker, J.L.Schipper, P.D.Swartz, A.C.Clark, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.87 / 1.54
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	69.027, 84.941, 96.459, 90.00, 90.00, 90.00
R / Rfree (%)	16 / 18.9

The binding sites of Sodium atom in the Caspase 3 V266Y (pdb code 5ias). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Caspase 3 V266Y, PDB code: 5ias:

Sodium binding site 1 out of 1 in the Caspase 3 V266Y


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Caspase 3 V266Y within 5.0Å range: probe atom residue distance (Å) B Occ A:Na301 b:15.0 occ:1.00 OE1 A:GLN161 2.8 8.6 1.0 O A:TRP206 2.8 7.8 1.0 N A:PHE215 2.9 8.7 1.0 NE2 A:GLN261 3.0 9.3 1.0 CB A:PHE215 3.2 7.4 1.0 OG A:SER205 3.3 10.2 1.0 N A:TRP214 3.4 7.2 1.0 CD A:GLN161 3.5 7.3 1.0 NE2 A:GLN161 3.6 9.8 1.0 CB A:SER213 3.6 9.5 1.0 CA A:PHE215 3.7 8.9 1.0 CB A:TRP214 3.8 10.0 1.0 C A:TRP214 3.9 8.0 1.0 C A:TRP206 3.9 7.1 1.0 CA A:TRP214 3.9 6.3 1.0 CD A:GLN261 3.9 10.1 1.0 N A:TRP206 4.0 8.0 1.0 OE1 A:GLN261 4.0 12.4 1.0 OG A:SER213 4.0 10.2 1.0 C A:SER213 4.1 8.6 1.0 CB A:SER198 4.1 9.8 1.0 CA A:SER213 4.3 8.1 1.0 CA A:TRP206 4.5 8.6 1.0 OG A:SER198 4.5 9.9 1.0 CG A:TRP214 4.6 9.7 1.0 CB A:SER205 4.6 8.5 1.0 CG A:PHE215 4.6 7.8 1.0 C A:SER205 4.8 8.2 1.0 N A:ILE216 4.8 6.7 1.0 C A:PHE215 4.8 6.6 1.0 O A:SER198 4.8 8.9 1.0 CG A:GLN161 4.9 6.9 1.0 O A:SER213 4.9 7.7 1.0 CB A:TRP206 5.0 7.8 1.0

J.J.Maciag, S.H.Mackenzie, M.B.Tucker, J.L.Schipper, P.Swartz, A.C.Clark. Tunable Allosteric Library of Caspase-3 Identifies Coupling Between Conserved Water Molecules and Conformational Selection. Proc.Natl.Acad.Sci.Usa V. 113 E6080 2016.
ISSN: ESSN 1091-6490
PubMed: 27681633
DOI: 10.1073/PNAS.1603549113