Sodium in PDB 5enn: The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor

All present enzymatic activity of The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor:
2.7.1.137;

The structure of The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor, PDB code: 5enn was solved by E.P.Kearney, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.01 / 2.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	113.726, 114.481, 143.903, 90.00, 90.00, 90.00
R / Rfree (%)	17.4 / 20.1

The binding sites of Sodium atom in the The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor (pdb code 5enn). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor, PDB code: 5enn:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Na902 b:62.2 occ:1.00 O A:HOH1059 3.3 60.0 1.0 CD A:PRO669 3.4 52.1 1.0 N A:PRO669 3.9 49.1 1.0 CA A:THR668 4.0 46.1 1.0 O A:LEU667 4.2 55.8 1.0 C A:THR668 4.2 50.0 1.0 CG2 A:THR668 4.3 34.9 1.0 NZ A:LYS756 4.3 86.1 1.0 C A:PRO669 4.5 48.1 1.0 CG A:PRO669 4.5 55.9 1.0 O A:PRO669 4.5 48.2 1.0 N A:TYR670 4.7 40.5 1.0 CB A:THR668 4.7 45.7 1.0 O A:HOH1053 4.7 48.2 1.0 CA A:PRO669 4.8 48.2 1.0

Sodium binding site 2 out of 2 in the The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of The Crystal Structure of Human VPS34 in Complex with A Selective and Potent Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ B:Na902 b:69.1 occ:1.00 CE B:MET394 4.0 54.4 0.5 OH B:TYR496 4.0 44.5 1.0 O B:HOH1127 4.1 55.5 1.0 O B:LEU393 4.3 47.8 1.0 O B:HOH1016 4.3 54.3 1.0 CZ B:TYR492 4.5 44.8 1.0 CE1 B:TYR492 4.5 34.7 1.0 CG B:GLN649 4.6 63.6 1.0 CE2 B:TYR492 4.8 40.4 1.0 CD1 B:TYR492 4.8 36.6 1.0 OH B:TYR492 4.9 50.6 1.0 CG B:LEU393 5.0 55.5 1.0

E.P.Kearney, E.P.Kearney. N/A N/A.