Sodium in PDB 5czg: Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine

The structure of Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine, PDB code: 5czg was solved by D.Q.Jiang, W.Tempel, P.Loppnau, S.Graslund, C.H.Arrowsmith, A.M.Edwards, C.Bountra, R.Hui, M.Amani, C.F.D.Hou, Structural Genomics Consortium(Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.77 / 1.45
Space group	P 43 2 2
Cell size a, b, c (Å), α, β, γ (°)	36.766, 36.766, 162.210, 90.00, 90.00, 90.00
R / Rfree (%)	16.2 / 21.4

The binding sites of Sodium atom in the Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine (pdb code 5czg). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine, PDB code: 5czg:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine within 5.0Å range: probe atom residue distance (Å) B Occ A:Na501 b:17.4 occ:1.00 O A:HOH689 2.4 18.3 0.5 O A:GLY0 2.4 16.9 1.0 O A:HOH649 2.4 15.0 1.0 H2 A:GLY0 3.1 21.7 1.0 C A:GLY0 3.2 15.6 1.0 HA A:MET1 3.7 20.7 1.0 HA2 A:GLY0 3.8 23.6 1.0 CA A:GLY0 3.8 19.6 1.0 N A:GLY0 3.8 18.1 1.0 N A:MET1 4.1 16.1 1.0 O A:HOH653 4.1 31.4 1.0 O A:HOH690 4.2 28.1 1.0 O A:HOH648 4.3 21.6 1.0 H1 A:GLY0 4.3 21.7 1.0 CA A:MET1 4.4 17.3 1.0 H3 A:GLY0 4.4 21.7 1.0 OE1 A:GLU5 4.7 17.4 1.0 HA3 A:GLY0 4.7 23.6 1.0 H A:MET1 4.8 19.3 1.0 O A:HOH614 5.0 17.2 1.0 HG3 A:MET1 5.0 29.1 1.0

Sodium binding site 2 out of 2 in the Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure Analysis of Hypothetical Bromodomain TB427.10.7420 From Trypanosoma Brucei in Complex with Bromosporine within 5.0Å range: probe atom residue distance (Å) B Occ A:Na502 b:14.4 occ:1.00 O A:PHE10 2.2 16.0 1.0 O A:ASN4 2.3 16.6 1.0 O A:ASP7 2.3 15.3 1.0 O A:HOH685 2.5 26.2 1.0 O A:HOH618 2.5 14.7 1.0 O A:HOH668 2.6 23.5 1.0 C A:ASN4 3.4 15.2 1.0 C A:PHE10 3.5 13.9 1.0 C A:ASP7 3.5 13.1 1.0 HA A:ASN11 3.5 17.7 1.0 HA A:THR8 3.7 16.0 1.0 HB3 A:ASP7 3.7 21.2 1.0 H A:PHE10 3.8 19.0 1.0 HA A:GLU5 3.9 16.6 1.0 HB3 A:ASN4 4.0 21.5 1.0 HA A:ASN4 4.1 19.3 1.0 HB3 A:PHE10 4.2 17.0 1.0 H A:ASP7 4.2 16.3 1.0 OD1 A:ASN11 4.2 19.6 1.0 O A:GLU5 4.3 13.5 1.0 CA A:ASN4 4.3 16.1 1.0 N A:GLU5 4.3 14.5 1.0 HD2 A:PHE10 4.3 18.1 1.0 CA A:ASN11 4.3 14.8 1.0 N A:ASN11 4.3 13.7 1.0 CA A:ASP7 4.4 14.4 1.0 N A:THR8 4.4 13.1 1.0 CA A:GLU5 4.4 13.9 1.0 CB A:ASP7 4.4 17.7 1.0 CA A:THR8 4.4 13.3 1.0 N A:PHE10 4.4 15.8 1.0 O A:HOH691 4.4 25.3 1.0 CA A:PHE10 4.4 12.8 1.0 H A:LYS12 4.4 19.1 1.0 C A:GLU5 4.5 14.2 1.0 N A:ASP7 4.5 13.6 1.0 CB A:ASN4 4.7 17.9 1.0 CB A:PHE10 4.8 14.2 1.0 CG A:ASN11 4.9 17.4 1.0 CG A:ASP7 4.9 20.6 1.0 H A:SER9 4.9 17.8 1.0 CD2 A:PHE10 5.0 15.1 1.0

D.Q.Jiang, W.Tempel, P.Loppnau, S.Graslund, C.H.Arrowsmith, A.M.Edwards, C.Bountra, R.Hui, M.Amani, C.F.D.Hou. Crystal Structure Analysis of Hypothetical Bromodomain From Trypanosoma Brucei To Be Published.