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Atomistry » Sodium » PDB 5cd1-5cwl » 5cni | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 5cd1-5cwl » 5cni » |
Sodium in PDB 5cni: MGLU2 with GlutamateProtein crystallography data
The structure of MGLU2 with Glutamate, PDB code: 5cni
was solved by
D.K.Clawson,
S.Atwell,
J.A.Monn,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5cni:
The structure of MGLU2 with Glutamate also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the MGLU2 with Glutamate
(pdb code 5cni). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the MGLU2 with Glutamate, PDB code: 5cni: Jump to Sodium binding site number: 1; 2; Sodium binding site 1 out of 2 in 5cniGo back to Sodium Binding Sites List in 5cni
Sodium binding site 1 out
of 2 in the MGLU2 with Glutamate
Mono view Stereo pair view
Sodium binding site 2 out of 2 in 5cniGo back to Sodium Binding Sites List in 5cni
Sodium binding site 2 out
of 2 in the MGLU2 with Glutamate
Mono view Stereo pair view
Reference:
J.A.Monn,
L.Prieto,
L.Taboada,
J.Hao,
M.R.Reinhard,
S.S.Henry,
C.D.Beadle,
L.Walton,
T.Man,
H.Rudyk,
B.Clark,
D.Tupper,
S.R.Baker,
C.Lamas,
C.Montero,
A.Marcos,
J.Blanco,
M.Bures,
D.K.Clawson,
S.Atwell,
F.Lu,
J.Wang,
M.Russell,
B.A.Heinz,
X.Wang,
J.H.Carter,
B.G.Getman,
J.T.Catlow,
S.Swanson,
B.G.Johnson,
D.B.Shaw,
D.L.Mckinzie.
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl) -Substituted-2-Aminobicyclo[3.1.0]Hexane-2,6-Dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-Triazol-3-Ylsulfanyl) Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid (LY2812223), A Highly Potent, Functionally Selective MGLU2 Receptor Agonist. J.Med.Chem. V. 58 7526 2015.
Page generated: Mon Oct 7 20:23:17 2024
ISSN: ISSN 0022-2623 PubMed: 26313429 DOI: 10.1021/ACS.JMEDCHEM.5B01124 |
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