Sodium in PDB 5aeq: Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus

The structure of Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus, PDB code: 5aeq was solved by M.Saleem, V.Karuppiah, S.Pandalaneni, R.Burgoyne, J.P.Derrick, L.Y.Lian, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	77.13 / 1.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	53.910, 55.490, 77.360, 90.00, 94.42, 90.00
R / Rfree (%)	22.499 / 25.37

The structure of Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus also contains other interesting chemical elements:

Calcium

(Ca)

6 atoms

The binding sites of Sodium atom in the Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus (pdb code 5aeq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus, PDB code: 5aeq:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus within 5.0Å range: probe atom residue distance (Å) B Occ A:Na203 b:11.1 occ:1.00 O A:HOH2074 2.2 10.9 1.0 O A:ALA175 2.3 13.7 1.0 C A:ALA175 3.2 13.8 1.0 CD A:PRO177 3.8 15.6 1.0 CG A:PRO177 3.8 16.1 1.0 CA A:ALA175 3.9 13.3 1.0 N A:ASP176 4.2 14.8 1.0 O A:LYS174 4.2 13.5 1.0 N A:PRO177 4.3 14.9 1.0 CA A:ASP176 4.6 16.0 1.0 C A:ASP176 4.7 14.8 1.0 CB A:ALA175 4.8 12.8 1.0 CA A:PRO177 4.9 15.3 1.0 CB A:PRO177 4.9 16.1 1.0 N A:ALA175 4.9 13.0 1.0 C A:LYS174 5.0 13.7 1.0

Sodium binding site 2 out of 2 in the Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Neuronal Calcium Sensor (Ncs-1)From Rattus Norvegicus within 5.0Å range: probe atom residue distance (Å) B Occ B:Na203 b:17.6 occ:1.00 O B:HOH2005 2.2 20.2 1.0 O B:THR17 2.2 26.7 1.0 O B:THR20 2.2 25.0 1.0 O B:PHE22 2.2 23.3 1.0 C B:THR20 3.3 23.7 1.0 C B:PHE22 3.3 22.1 1.0 C B:THR17 3.4 26.6 1.0 N B:PHE22 3.5 21.4 1.0 CG2 B:THR17 3.8 25.2 1.0 C B:TYR21 3.8 21.7 1.0 OG1 B:THR20 4.0 24.6 1.0 CA B:THR17 4.0 25.4 1.0 CA B:PHE22 4.0 21.5 1.0 CA B:TYR21 4.0 22.2 1.0 N B:TYR21 4.0 22.3 1.0 CA B:THR20 4.3 24.3 1.0 N B:THR20 4.3 26.0 1.0 N B:THR23 4.4 22.2 1.0 N B:ARG18 4.5 29.4 1.0 CB B:THR17 4.6 25.6 1.0 O B:TYR21 4.6 21.4 1.0 CB B:THR20 4.8 24.1 1.0 CA B:ARG18 4.8 32.2 1.0 CA B:THR23 4.8 23.0 1.0 CB B:PHE22 5.0 21.5 1.0 O B:LEU16 5.0 23.5 1.0 C B:ARG18 5.0 31.9 1.0

S.Pandalaneni, V.Karuppiah, M.Saleem, L.P.Haynes, R.Burgoyne, O.Mayans, J.P.Derrick, L.Y.Lian. Structures of Ncs-1 Complexes with the D2 Dopamine Receptor and Gpcr Kinase 1 (GRK1) Peptides Shows Different Modes of Interactions To Be Published.