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Sodium in PDB 4z9v: Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl

Protein crystallography data

The structure of Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl, PDB code: 4z9v was solved by V.Cura, M.Agez, S.Thebault, J.Cavarelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.54 / 2.10
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 100.357, 100.357, 105.045, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 22.2

Sodium Binding Sites:

The binding sites of Sodium atom in the Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl (pdb code 4z9v). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl, PDB code: 4z9v:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 4z9v

Go back to Sodium Binding Sites List in 4z9v
Sodium binding site 1 out of 2 in the Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Na101

b:0.2
occ:1.00
O F:CYS28 3.1 58.6 1.0
O F:ASP25 3.2 66.4 1.0
O F:GLU30 3.2 0.1 1.0
C F:GLU30 3.4 1.0 1.0
CA F:ASP25 3.5 59.7 1.0
C F:ASP25 3.7 63.5 1.0
OD1 F:ASP25 3.9 75.4 1.0
C F:CYS28 4.2 53.0 1.0
O F:ALA24 4.2 49.8 1.0
CB F:ASP25 4.2 67.1 1.0
OG B:SER164 4.3 57.6 1.0
O F:LEU29 4.4 82.9 1.0
C F:LEU29 4.5 85.3 1.0
CG F:ASP25 4.5 73.8 1.0
N F:ASP25 4.6 52.4 1.0
N F:GLU30 4.6 96.1 1.0
CA F:GLU30 4.6 0.9 1.0
C F:ALA24 4.8 52.2 1.0
O B:HOH416 4.9 65.3 1.0
CB F:CYS28 5.0 57.4 1.0
CA F:CYS28 5.0 58.5 1.0

Sodium binding site 2 out of 2 in 4z9v

Go back to Sodium Binding Sites List in 4z9v
Sodium binding site 2 out of 2 in the Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Na101

b:0.3
occ:1.00
O B:HOH406 2.4 59.2 1.0
O A:HOH408 2.5 55.1 1.0
O G:HOH102 2.6 61.0 1.0
OE2 H:GLU30 3.4 76.2 1.0
NZ A:LYS87 3.8 42.0 1.0
NZ B:LYS87 4.1 49.5 1.0
OE2 G:GLU30 4.1 60.0 1.0
CD H:GLU30 4.3 63.8 1.0
OE1 H:GLU30 4.4 51.4 1.0
O A:HOH419 4.4 57.5 1.0
OD2 B:ASP11 4.4 50.3 1.0
OD1 A:ASP11 4.5 48.6 1.0
O2 A:BCT301 4.5 79.5 1.0
CD G:GLU30 4.8 55.6 1.0
O2 B:BCT301 4.8 81.5 1.0
OE1 G:GLU30 4.9 61.2 1.0

Reference:

S.Thebault, M.Agez, X.Chi, J.Stojko, V.Cura, S.B.Telerman, L.Maillet, F.Gautier, I.Billas-Massobrio, C.Birck, N.Troffer-Charlier, T.Karafin, J.Honore, A.Senff-Ribeiro, S.Montessuit, C.M.Johnson, P.Juin, S.Cianferani, J.C.Martinou, D.W.Andrews, R.Amson, A.Telerman, J.Cavarelli. Tctp Contains A BH3-Like Domain, Which Instead of Inhibiting, Activates Bcl-Xl. Sci Rep V. 6 19725 2016.
ISSN: ESSN 2045-2322
PubMed: 26813996
DOI: 10.1038/SREP19725
Page generated: Tue Dec 15 10:05:55 2020

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