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Sodium in PDB 4y6g: Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site.

Enzymatic activity of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site.

All present enzymatic activity of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site.:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site., PDB code: 4y6g was solved by E.Hilario, B.G.Caulkins, R.P.Young, M.F.Dunn, L.J.Mueller, L.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.69 / 1.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 184.170, 59.840, 67.300, 90.00, 94.91, 90.00
R / Rfree (%) 15.8 / 17.9

Other elements in 4y6g:

The structure of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site. also contains other interesting chemical elements:

Fluorine (F) 6 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site. (pdb code 4y6g). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site., PDB code: 4y6g:

Sodium binding site 1 out of 1 in 4y6g

Go back to Sodium Binding Sites List in 4y6g
Sodium binding site 1 out of 1 in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site.


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with N-(4'-Trifluoromethoxybenzoyl)-2-Amino-1- Ethylphosphate (F6F) Inhibitor in the Alpha-Site and Beta-Site. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na403

b:16.7
occ:1.00
O B:HOH921 2.3 24.4 1.0
O B:GLY232 2.3 18.8 1.0
O B:SER308 2.3 17.8 1.0
O B:HOH922 2.3 17.8 1.0
O B:PHE306 2.3 29.0 1.0
C B:GLY232 3.4 16.7 1.0
C B:PHE306 3.4 30.9 1.0
C B:SER308 3.5 18.3 1.0
CG B:PRO270 3.8 15.1 1.0
CD B:PRO270 3.9 15.3 1.0
N B:SER308 4.0 21.8 1.0
CA B:GLY232 4.0 15.9 1.0
CB B:PHE306 4.1 32.6 1.0
O B:GLY268 4.1 16.4 1.0
CA B:PHE306 4.2 31.3 1.0
CD2 B:PHE306 4.3 29.2 1.0
CA B:SER308 4.3 19.2 1.0
N B:VAL309 4.4 16.6 1.0
O B:LEU304 4.5 23.2 1.0
O B:VAL231 4.5 15.3 1.0
N B:PRO307 4.5 31.9 1.0
N B:PHE306 4.5 34.1 1.0
N B:GLY233 4.5 15.5 1.0
CA B:VAL309 4.5 15.6 1.0
C B:PRO307 4.6 25.0 1.0
OG B:SER297 4.6 34.1 1.0
CG B:PHE306 4.6 32.5 1.0
CB B:VAL309 4.6 16.1 1.0
CA B:PRO307 4.7 28.1 1.0
OE2 B:GLU256 4.8 15.5 1.0
CA B:GLY233 4.9 15.1 1.0
N B:GLY232 5.0 14.8 1.0
C B:GLY268 5.0 16.5 1.0

Reference:

E.Hilario, B.G.Caulkins, Y.M.Huang, W.You, C.E.Chang, L.J.Mueller, M.F.Dunn, L.Fan. Visualizing the Tunnel in Tryptophan Synthase with Crystallography: Insights Into A Selective Filter For Accommodating Indole and Rejecting Water. Biochim.Biophys.Acta V.1864 268 2016.
ISSN: ISSN 0006-3002
PubMed: 26708480
DOI: 10.1016/J.BBAPAP.2015.12.006
Page generated: Tue Dec 15 10:01:13 2020

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