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Sodium in PDB 4php: Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese

Enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese

All present enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese, PDB code: 4php was solved by M.C.Koag, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.83 / 2.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.701, 79.327, 55.474, 90.00, 107.58, 90.00
R / Rfree (%) 18.1 / 26.2

Other elements in 4php:

The structure of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese (pdb code 4php). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese, PDB code: 4php:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 4php

Go back to Sodium Binding Sites List in 4php
Sodium binding site 1 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na403

b:14.9
occ:1.00
O A:THR101 2.3 12.6 1.0
OP1 P:DG9 2.4 11.3 1.0
O A:HOH534 2.5 14.5 1.0
O A:ILE106 2.6 12.4 1.0
O A:VAL103 2.8 13.8 1.0
O P:HOH103 3.2 18.4 1.0
P P:DG9 3.3 11.7 1.0
OP2 P:DG9 3.3 14.7 1.0
C A:THR101 3.4 12.3 1.0
C A:VAL103 3.5 13.8 1.0
C A:ILE106 3.6 15.5 1.0
N A:ILE106 3.9 18.4 1.0
CA A:SER104 3.9 11.6 1.0
N A:GLY105 4.0 16.5 1.0
N A:SER104 4.1 13.4 1.0
CA A:THR101 4.1 14.8 1.0
CA A:ILE106 4.2 12.9 1.0
N A:VAL103 4.3 12.5 1.0
C A:ARG102 4.3 16.3 1.0
O3' P:DC8 4.3 13.7 1.0
N A:ARG102 4.4 11.5 1.0
C A:SER104 4.4 16.0 1.0
O5' P:DG9 4.5 16.1 1.0
CA A:VAL103 4.6 14.1 1.0
CA A:ARG102 4.6 14.7 1.0
N A:GLY107 4.6 15.2 1.0
CB A:THR101 4.6 11.8 1.0
CB A:ILE106 4.7 10.8 1.0
O A:ARG102 4.7 19.1 1.0
C A:GLY105 4.7 17.2 1.0
CA A:GLY107 4.9 14.1 1.0

Sodium binding site 2 out of 2 in 4php

Go back to Sodium Binding Sites List in 4php
Sodium binding site 2 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Structure of Human Dna Polymerase Beta Complexed with T in the Template Base Paired with Incoming Non-Hydrolyzable Gtp and Manganese within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na404

b:15.9
occ:1.00
OP1 D:DC3 2.4 33.3 1.0
O A:LYS60 2.5 25.1 1.0
O A:HOH540 2.5 24.0 1.0
O A:VAL65 2.5 21.1 1.0
O A:LEU62 2.5 20.7 1.0
C A:VAL65 3.5 18.3 1.0
C A:LEU62 3.5 23.0 1.0
C A:LYS60 3.6 24.9 1.0
P D:DC3 3.6 27.2 1.0
N A:VAL65 3.8 20.4 1.0
OP2 D:DC3 3.9 23.9 1.0
CA A:VAL65 4.1 19.1 1.0
N A:LEU62 4.1 21.3 1.0
C A:LYS61 4.2 19.1 1.0
N A:GLY64 4.2 22.9 1.0
N A:PRO63 4.3 25.1 1.0
CA A:PRO63 4.4 25.7 1.0
O A:LYS61 4.4 22.4 1.0
CB A:VAL65 4.4 22.9 1.0
CA A:LYS60 4.4 21.4 1.0
CA A:LEU62 4.5 19.9 1.0
N A:LYS61 4.5 24.4 1.0
N A:GLY66 4.5 19.8 1.0
CA A:LYS61 4.6 17.4 1.0
O3' D:DT2 4.6 26.4 1.0
C A:PRO63 4.7 28.8 1.0
O5' D:DC3 4.7 28.1 1.0
CG A:LYS60 4.8 27.1 1.0
CA A:GLY66 4.8 18.1 1.0
C A:GLY64 4.8 22.1 1.0
O A:ALA59 5.0 18.5 1.0

Reference:

M.C.Koag, S.Lee. The Spontaneous Base Substitution Mechanisms of Human Dna Polymerase Beta To Be Published.
Page generated: Tue Dec 15 06:58:16 2020

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