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Sodium in PDB 4j9m: Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G)

Enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G)

All present enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G):
2.7.7.7;

Protein crystallography data

The structure of Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G), PDB code: 4j9m was solved by Y.Zhao, M.Gregory, C.Biertumpfel, Y.Hua, F.Hanaoka, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.55 / 2.25
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 98.430, 98.430, 82.010, 90.00, 90.00, 120.00
R / Rfree (%) 18 / 22.3

Other elements in 4j9m:

The structure of Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G) also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G) (pdb code 4j9m). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G), PDB code: 4j9m:

Sodium binding site 1 out of 1 in 4j9m

Go back to Sodium Binding Sites List in 4j9m
Sodium binding site 1 out of 1 in the Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Dna Polymerase Eta-Dna Ternary Complex: Misincorporation G Opposite T After An A at the Primer 3' End (Aa/G) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na503

b:36.0
occ:1.00
O A:PRO27 2.9 13.3 1.0
O A:ARG30 3.1 11.8 1.0
O A:HIS28 3.1 17.6 1.0
C A:HIS28 3.4 18.9 1.0
CA A:HIS28 3.7 18.9 1.0
N A:ARG30 3.9 13.1 1.0
C A:PRO27 3.9 10.3 1.0
C A:ARG30 4.0 15.5 1.0
CE A:LYS32 4.1 33.0 1.0
N A:LEU29 4.2 14.0 1.0
CA A:ARG30 4.3 14.0 1.0
N A:HIS28 4.3 15.9 1.0
CG A:LYS32 4.3 21.8 1.0
CB A:ARG30 4.3 14.3 1.0
C A:LEU29 4.5 13.6 1.0
CD A:LYS32 4.6 28.8 1.0
CA A:LEU29 4.8 16.7 1.0
CB A:HIS28 5.0 23.0 1.0

Reference:

Y.Zhao, M.T.Gregory, C.Biertumpfel, Y.J.Hua, F.Hanaoka, W.Yang. Mechanism of Somatic Hypermutation at the Wa Motif By Human Dna Polymerase Eta. Proc.Natl.Acad.Sci.Usa V. 110 8146 2013.
ISSN: ISSN 0027-8424
PubMed: 23630267
DOI: 10.1073/PNAS.1303126110
Page generated: Mon Oct 7 16:13:29 2024

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