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Atomistry » Sodium » PDB 4iic-4j0n » 4iqu » |
Sodium in PDB 4iqu: Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic AcidEnzymatic activity of Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid
All present enzymatic activity of Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid:
2.7.7.31; Protein crystallography data
The structure of Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid, PDB code: 4iqu
was solved by
J.Gouge,
M.Delarue,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4iqu:
The structure of Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid
(pdb code 4iqu). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid, PDB code: 4iqu: Sodium binding site 1 out of 1 in 4iquGo back to![]() ![]()
Sodium binding site 1 out
of 1 in the Tdt Core in Complex with Inhibitor (2Z,5E)-6-[4-(4-Fluorobenzoyl)-1H- Pyrrol-2-Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid
![]() Mono view ![]() Stereo pair view
Reference:
R.Costi,
G.Cuzzucoli Crucitti,
L.Pescatori,
A.Messore,
L.Scipione,
S.Tortorella,
A.Amoroso,
E.Crespan,
P.Campiglia,
B.Maresca,
A.Porta,
I.Granata,
E.Novellino,
J.Gouge,
M.Delarue,
G.Maga,
R.Di Santo.
New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target. J.Med.Chem. V. 56 7431 2013.
Page generated: Tue Dec 15 06:45:08 2020
ISSN: ISSN 0022-2623 PubMed: 23968551 DOI: 10.1021/JM4010187 |
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