Sodium in PDB 4fxz: Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles

The structure of Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles, PDB code: 4fxz was solved by H.Wang, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.30 / 2.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	122.140, 89.888, 81.262, 90.00, 102.95, 90.00
R / Rfree (%)	21.3 / 22

The binding sites of Sodium atom in the Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles (pdb code 4fxz). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles, PDB code: 4fxz:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:32.9 occ:1.00 O A:ALA22 2.3 35.9 1.0 OD1 A:ASN27 2.3 42.9 1.0 O A:THR254 2.4 34.1 1.0 OG1 A:THR254 2.4 41.2 1.0 OD1 A:ASN286 2.4 40.6 1.0 O A:LEU601 2.6 39.9 1.0 C A:ALA22 3.1 35.0 1.0 C A:THR254 3.1 38.3 1.0 CG A:ASN27 3.2 41.2 1.0 CA A:THR254 3.2 39.2 1.0 ND2 A:ASN27 3.3 38.2 1.0 CB A:THR254 3.4 41.5 1.0 CG A:ASN286 3.4 35.5 1.0 ND2 A:ASN286 3.6 35.7 1.0 C A:LEU601 3.6 39.9 1.0 N A:VAL23 3.7 36.4 1.0 CA A:VAL23 3.8 35.0 1.0 N A:LEU601 3.8 36.2 1.0 N A:GLY24 3.9 38.2 1.0 CA A:ALA22 4.0 34.2 1.0 OE2 A:GLU290 4.2 40.7 1.0 CA A:LEU601 4.3 34.7 1.0 C A:VAL23 4.3 37.9 1.0 CB A:ALA22 4.4 32.0 1.0 N A:LEU255 4.4 37.0 1.0 CG2 A:THR254 4.4 41.1 1.0 OXT A:LEU601 4.5 35.8 1.0 N A:THR254 4.6 37.6 1.0 CB A:ASN27 4.6 42.9 1.0 N A:ASN27 4.6 37.7 1.0 CB A:ASN286 4.8 39.4 1.0 O A:ALA253 4.9 36.9 1.0 CA A:GLY24 4.9 36.4 1.0 C A:GLY26 4.9 43.8 1.0

Sodium binding site 2 out of 2 in the Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Leut-F253A Bound to L-Leucine From Lipid Bicelles within 5.0Å range: probe atom residue distance (Å) B Occ A:Na603 b:40.4 occ:1.00 O A:GLY20 2.2 38.2 1.0 O A:ALA351 2.3 44.7 1.0 O A:VAL23 2.4 39.4 1.0 OG1 A:THR354 2.4 38.0 1.0 OG A:SER355 2.4 39.0 1.0 N A:SER355 2.6 37.3 1.0 C A:THR354 3.0 37.4 1.0 CB A:THR354 3.1 41.6 1.0 CA A:SER355 3.2 36.1 1.0 CB A:SER355 3.2 41.0 1.0 C A:VAL23 3.3 37.9 1.0 C A:ALA351 3.4 38.4 1.0 C A:GLY20 3.4 43.3 1.0 CA A:THR354 3.5 35.9 1.0 CA A:GLY24 3.7 36.4 1.0 O A:THR354 3.7 38.0 1.0 N A:GLY24 3.9 38.2 1.0 CA A:ALA351 3.9 40.5 1.0 N A:THR354 4.0 35.1 1.0 O A:ASN21 4.1 38.9 1.0 CA A:GLY20 4.2 42.3 1.0 N A:ASN21 4.4 46.3 1.0 C A:ASN21 4.4 39.0 1.0 N A:GLY352 4.5 33.8 1.0 CA A:VAL23 4.5 35.0 1.0 CG2 A:THR354 4.6 42.5 1.0 CA A:ASN21 4.6 37.6 1.0 N A:VAL23 4.6 36.4 1.0 O A:PHE350 4.6 39.9 1.0 CB A:ALA351 4.7 34.5 1.0 O A:GLY352 4.7 40.2 1.0 C A:SER355 4.7 40.2 1.0 C A:GLY352 4.7 40.7 1.0 C A:LEU353 4.9 43.2 1.0 C A:ALA22 4.9 35.0 1.0 CA A:GLY352 4.9 39.8 1.0 O A:ALA22 5.0 35.9 1.0

H.Wang, E.Gouaux. Substrate Binds in the S1 Site of the F253A Mutant of Leut, A Neurotransmitter Sodium Symporter Homologue. Embo Rep. V. 13 861 2012.
ISSN: ISSN 1469-221X
PubMed: 22836580
DOI: 10.1038/EMBOR.2012.110