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Atomistry » Sodium » PDB 4dy7-4egs » 4e96 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 4dy7-4egs » 4e96 » |
Sodium in PDB 4e96: Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Pfi-1Protein crystallography data
The structure of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Pfi-1, PDB code: 4e96
was solved by
P.Filippakopoulos,
S.Picaud,
I.Felletar,
O.Fedorov,
F.Von Delft,
C.H.Arrowsmith,
A.M.Edwards,
J.Weigelt,
P.Fish,
M.Bunnage,
D.Owen,
S.Knapp,
A.Cook,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Pfi-1
(pdb code 4e96). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Pfi-1, PDB code: 4e96: Sodium binding site 1 out of 1 in 4e96Go back to Sodium Binding Sites List in 4e96
Sodium binding site 1 out
of 1 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Pfi-1
Mono view Stereo pair view
Reference:
P.V.Fish,
P.Filippakopoulos,
G.Bish,
P.E.Brennan,
M.E.Bunnage,
A.S.Cook,
O.Federov,
B.S.Gerstenberger,
H.Jones,
S.Knapp,
B.Marsden,
K.Nocka,
D.R.Owen,
M.Philpott,
S.Picaud,
M.J.Primiano,
M.J.Ralph,
N.Sciammetta,
J.D.Trzupek.
Identification of A Chemical Probe For Bromo and Extra C-Terminal Bromodomain Inhibition Through Optimization of A Fragment-Derived Hit. J.Med.Chem. V. 55 9831 2012.
Page generated: Tue Dec 15 06:38:28 2020
ISSN: ISSN 0022-2623 PubMed: 23095041 DOI: 10.1021/JM3010515 |
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