Sodium in PDB 4bgq: Crystal Structure of the Human CDKL5 Kinase Domain

All present enzymatic activity of Crystal Structure of the Human CDKL5 Kinase Domain:
2.7.11.22;

The structure of Crystal Structure of the Human CDKL5 Kinase Domain, PDB code: 4bgq was solved by P.Canning, T.Krojer, S.Goubin, P.Mahajan, M.Vollmar, A.C.W.Pike, F.Vondelft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.26 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	51.942, 65.507, 102.899, 90.00, 90.00, 90.00
R / Rfree (%)	17.4 / 20.1

The binding sites of Sodium atom in the Crystal Structure of the Human CDKL5 Kinase Domain (pdb code 4bgq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of the Human CDKL5 Kinase Domain, PDB code: 4bgq:

Sodium binding site 1 out of 1 in the Crystal Structure of the Human CDKL5 Kinase Domain


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Human CDKL5 Kinase Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1003 b:20.3 occ:1.00 N A:GLU93 3.3 23.0 1.0 N A:HIS145 3.4 32.7 1.0 ND1 A:HIS145 3.6 46.1 1.0 CA A:SER144 3.6 25.6 1.0 CB A:SER144 3.7 24.9 1.0 CA A:VAL92 3.9 20.8 1.0 CB A:GLU93 3.9 27.2 1.0 C A:SER144 3.9 28.3 1.0 CG A:GLU93 4.0 28.8 1.0 C A:VAL92 4.0 21.3 1.0 CA A:GLU93 4.1 24.5 1.0 CG1 A:VAL92 4.2 22.1 1.0 CB A:HIS145 4.3 39.9 1.0 O A:TYR91 4.3 19.0 1.0 CG A:HIS145 4.4 42.9 1.0 CA A:HIS145 4.4 37.3 1.0 O A:HOH2044 4.6 39.5 1.0 CE1 A:HIS145 4.6 47.0 1.0 CB A:VAL92 4.6 21.2 1.0 CD A:GLU93 4.7 32.0 1.0 OE1 A:GLU93 4.8 33.7 1.0 N A:SER144 4.8 23.1 1.0 OG A:SER144 4.9 26.3 1.0 N A:VAL92 4.9 19.8 1.0 O A:ILE143 5.0 22.3 1.0

P.Canning, T.Krojer, S.Goubin, P.Mahajan, M.Vollmar, A.C.W.Pike, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock. Crystal Structure of the Human CDKL5 Kinase Domain To Be Published.