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Atomistry » Sodium » PDB 3t0a-3tjl » 3t5f | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 3t0a-3tjl » 3t5f » |
Sodium in PDB 3t5f: Human Thrombin in Complex with MI340Enzymatic activity of Human Thrombin in Complex with MI340
All present enzymatic activity of Human Thrombin in Complex with MI340:
3.4.21.5; Protein crystallography data
The structure of Human Thrombin in Complex with MI340, PDB code: 3t5f
was solved by
A.Biela,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3t5f:
The structure of Human Thrombin in Complex with MI340 also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Human Thrombin in Complex with MI340
(pdb code 3t5f). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Thrombin in Complex with MI340, PDB code: 3t5f: Jump to Sodium binding site number: 1; 2; Sodium binding site 1 out of 2 in 3t5fGo back to Sodium Binding Sites List in 3t5f
Sodium binding site 1 out
of 2 in the Human Thrombin in Complex with MI340
Mono view Stereo pair view
Sodium binding site 2 out of 2 in 3t5fGo back to Sodium Binding Sites List in 3t5f
Sodium binding site 2 out
of 2 in the Human Thrombin in Complex with MI340
Mono view Stereo pair view
Reference:
A.Biela,
F.Sielaff,
F.Terwesten,
A.Heine,
T.Steinmetzer,
G.Klebe.
Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect J.Med.Chem. V. 55 6094 2012.
Page generated: Mon Oct 7 13:10:21 2024
ISSN: ISSN 0022-2623 PubMed: 22612268 DOI: 10.1021/JM300337Q |
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